Moschovaki-Zeiger Ornella, Arkoudis Nikolaos-Achilleas, Giannakis Athanasios, Grigoriadis Stavros, Anagnostopoulos Fotis, Spiliopoulos Stavros
2nd Department of Radiology, School of Medicine, "Attikon" University General Hospital, National and Kapodistrian University of Athens, GR-124 62 Chaidari, Greece.
Research Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, GR-115 28 Athens, Greece.
Medicina (Kaunas). 2024 Apr 22;60(4):678. doi: 10.3390/medicina60040678.
Transarterial chemoembolization (TACE) has revolutionized the treatment landscape for malignant liver disease, offering localized therapy with reduced systemic toxicity. This manuscript delves into the use of degradable microspheres (DMS) in TACE, exploring its potential advantages and clinical applications. DMS-TACE emerges as a promising strategy, offering temporary vessel occlusion and optimized drug delivery. The manuscript reviews the existing literature on DMS-TACE, emphasizing its tolerability, toxicity, and efficacy. Notably, DMS-TACE demonstrates versatility in patient selection, being suitable for both intermediate and advanced stages. The unique properties of DMS provide advantages over traditional embolic agents. The manuscript discusses the DMS-TACE procedure, adverse events, and tumor response rates in HCC, ICC, and metastases.
经动脉化疗栓塞术（TACE）彻底改变了恶性肝病的治疗格局，提供了局部治疗且全身毒性降低。本文深入探讨了可降解微球（DMS）在TACE中的应用，探索其潜在优势和临床应用。DMS-TACE作为一种有前景的策略出现，可提供临时血管闭塞和优化的药物递送。本文回顾了关于DMS-TACE的现有文献，强调其耐受性、毒性和疗效。值得注意的是，DMS-TACE在患者选择方面具有通用性，适用于中期和晚期阶段。DMS的独特特性优于传统栓塞剂。本文讨论了DMS-TACE在肝癌、肝内胆管癌和转移瘤中的操作过程、不良事件和肿瘤反应率。
