Kupisz-Urbanska Malgorzata, Marcinowska-Suchowierska Ewa, Jankowski Piotr
Department of Geriatrics, Medical Centre of Postgraduate Education, 01-813 Warsaw, Poland.
Department of Internal Medicine and Geriatric Cardiology, Medical Centre of Postgraduate Education, 01-813 Warsaw, Poland.
Nutrients. 2024 Apr 12;16(8):1141. doi: 10.3390/nu16081141.
The relationship between functional and nutritional status in the geriatric population remains an issue of debate and there is a gap in the knowledge regarding this field in long-lived individuals.
The main aim of this study was to assess the association between selected blood parameters of nutritional status and functional status in extreme longevity.
The inclusion criteria were centenarians above 100 years of age who were examined at their homes, and blood samples were collected. The study group consisted of 170 individuals (25 men and 145 women, median age 100.75 years [100.29-101.58]).
Total protein and albumin serum concentration was significantly lower in long-lived individuals with severe functional decline compared to individuals with preserved functional status, = 0.000001 and = 0.0000, respectively. Iron serum level was significantly higher in the group with preserved functional status, = 0.04. Preserved functional status was positively correlated with total protein serum concentration ( = 0.000), albumin concentration ( = 0.000), and iron serum level ( = 0.029). A negative correlation was stated between c-reactive protein (CRP) and functional status ( = 0.032). Univariable logistic regression analysis showed that the functional status of long-lived individuals depends on total protein (OR 2.89, CI 95% [1.67-5.0]) and albumin concentrations (OR 2.34, CI 95% [1.39-3.92]). Multivariable backward stepwise logistic regression analysis showed that a total protein concentration was the only variable independently related to the preserved functional status (OR 3.2, 95% Cl [1.8-5.67]).
In long-lived individuals, the total serum protein and albumin levels are lower in centenarians with severe functional decline, and they correlate with functional status. Total protein serum concentration is the only factor independently related to the preserved functional status in extreme longevity.
老年人群中功能状态与营养状况之间的关系仍是一个有争议的问题，并且在长寿个体中关于该领域的知识存在空白。
本研究的主要目的是评估极端长寿人群中营养状况的选定血液参数与功能状态之间的关联。
纳入标准为100岁以上在家接受检查的百岁老人，并采集血样。研究组由170名个体组成（25名男性和145名女性，中位年龄100.75岁[100.29 - 101.58]）。
与功能状态良好的个体相比，功能严重衰退的长寿个体血清总蛋白和白蛋白浓度显著降低，分别为P = 0.000001和P = 0.0000。功能状态良好组的血清铁水平显著更高，P = 0.04。功能状态良好与血清总蛋白浓度（P = 0.000）、白蛋白浓度（P = 0.000）和血清铁水平（P = 0.029）呈正相关。C反应蛋白（CRP）与功能状态之间呈负相关（P = 0.032）。单变量逻辑回归分析表明，长寿个体的功能状态取决于总蛋白（比值比2.89，95%置信区间[1.67 - 5.0]）和白蛋白浓度（比值比2.34，95%置信区间[1.39 - 3.92]）。多变量向后逐步逻辑回归分析表明，总蛋白浓度是唯一与功能状态良好独立相关的变量（比值比3.2，95%置信区间[1.8 - 5.67]）。
在长寿个体中，功能严重衰退的百岁老人血清总蛋白和白蛋白水平较低，且它们与功能状态相关。血清总蛋白浓度是极端长寿中与功能状态良好独立相关的唯一因素。
