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孕期、哺乳期及新生儿基于生理的药代动力学建模：成就、挑战与未来方向

Physiologically Based Pharmacokinetic Modeling in Pregnancy, during Lactation and in Neonates: Achievements, Challenges and Future Directions.

作者信息

Allegaert Karel, Quinney Sara K, Dallmann André

机构信息

Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.

Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.

出版信息

Pharmaceutics. 2024 Apr 5;16(4):500. doi: 10.3390/pharmaceutics16040500.

DOI:10.3390/pharmaceutics16040500
PMID:38675161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11053422/
Abstract

Obstetric subjects represent a special population in pharmacology [...].

摘要

产科受试者在药理学中代表着一个特殊群体[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2d/11053422/c4e63d52d79f/pharmaceutics-16-00500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2d/11053422/c4e63d52d79f/pharmaceutics-16-00500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2d/11053422/c4e63d52d79f/pharmaceutics-16-00500-g001.jpg

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Pharmaceutics. 2024 Jan 19;16(1):128. doi: 10.3390/pharmaceutics16010128.
2
Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam.妊娠相关激素可增加人肝细胞中细胞色素P450 3A（CYP3A）介导的丁丙诺啡代谢：与CYP3A底物硝苯地平和咪达唑仑的比较。
Front Pharmacol. 2023 Jul 5;14:1218703. doi: 10.3389/fphar.2023.1218703. eCollection 2023.
3
Physiologic Changes During Pregnancy and Impact on Small-Molecule Drugs, Biologic (Monoclonal Antibody) Disposition, and Response.妊娠期间的生理变化及其对小分子药物、生物（单克隆抗体）处置和反应的影响。
J Clin Pharmacol. 2023 Jun;63 Suppl 1(Suppl 1):S34-S50. doi: 10.1002/jcph.2227.
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The MPRINT Hub Data, Model, Knowledge and Research Coordination Center: Bridging the gap in maternal-pediatric therapeutics research through data integration and pharmacometrics.MPRINT 中心数据、模型、知识和研究协调中心：通过数据集成和药物动力学研究弥合母婴治疗学研究的差距。
Pharmacotherapy. 2023 May;43(5):391-402. doi: 10.1002/phar.2765. Epub 2023 Jan 25.
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