Wanek Thomas, Raabe Marco, Alam Md Noor A, Filip Thomas, Stanek Johann, Loebsch Mathilde, Laube Christian, Mairinger Severin, Weil Tanja, Kuntner Claudia
Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria.
Pharmaceuticals (Basel). 2024 Apr 17;17(4):514. doi: 10.3390/ph17040514.
Nanodiamonds (NDs) are emerging as a novel nanoparticle class with growing interest in medical applications. The surface coating of NDs can be modified by attaching binding ligands or imaging probes, turning them into multi-modal targeting agents. In this investigation, we assessed the targeting efficacy of octreotide-functionalized Ga-radiolabelled NDs for cancer imaging and compared it with the tumor uptake using [Ga]Ga-DOTA-TOC. In vivo studies in mice bearing AR42J tumors demonstrated the highest accumulation of the radiolabeled functionalized NDs in the liver and spleen, with relatively low tumor uptake compared to [Ga]Ga-DOTA-TOC. Our findings suggest that, within the scope of this study, functionalization did not enhance the tumor-targeting capabilities of NDs.
纳米金刚石（NDs）作为一类新型纳米颗粒，在医学应用方面的关注度日益增加。通过连接结合配体或成像探针可以对纳米金刚石的表面涂层进行修饰，使其成为多模态靶向剂。在本研究中，我们评估了奥曲肽功能化的镓放射性标记纳米金刚石用于癌症成像的靶向效果，并将其与使用[Ga]Ga-DOTA-TOC的肿瘤摄取情况进行了比较。在携带AR42J肿瘤的小鼠体内进行的研究表明，放射性标记的功能化纳米金刚石在肝脏和脾脏中的积累最高，与[Ga]Ga-DOTA-TOC相比，肿瘤摄取相对较低。我们的研究结果表明，在本研究范围内，功能化并未增强纳米金刚石的肿瘤靶向能力。
