Mouzannar Karim, Schauer Anne, Liang T Jake
Liver Diseases Branch, National Institute of Diabetics and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Viruses. 2024 Mar 29;16(4):528. doi: 10.3390/v16040528.
The post-transcriptional regulatory element (PRE) is present in all HBV mRNAs and plays a major role in their stability, nuclear export, and enhancement of viral gene expression. Understanding PRE's structure, function, and mode of action is essential to leverage its potential as a therapeutic target. A wide range of PRE-based reagents and tools have been developed and assessed in preclinical and clinical settings for therapeutic and biotechnology applications. This manuscript aims to provide a systematic review of the characteristics and mechanism of action of PRE, as well as elucidating its current applications in basic and clinical research. Finally, we discuss the promising opportunities that PRE may provide to antiviral development, viral biology, and potentially beyond.
转录后调控元件（PRE）存在于所有乙肝病毒（HBV）mRNA中，在其稳定性、核输出及病毒基因表达增强方面发挥主要作用。了解PRE的结构、功能及作用模式对于发挥其作为治疗靶点的潜力至关重要。已开发出多种基于PRE的试剂和工具，并在临床前和临床环境中进行了评估，以用于治疗和生物技术应用。本手稿旨在对PRE的特征和作用机制进行系统综述，并阐明其在基础研究和临床研究中的当前应用。最后，我们讨论了PRE可能为抗病毒研发、病毒生物学以及潜在的其他领域带来的有前景的机遇。
