Geng Jingke, Ren Nanjie, Yang Cihan, Wang Fei, Huang Doudou, Rodriguez Sergio, Yuan Zhiming, Xia Han
Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430200, China.
University of Chinese Academy of Sciences, Beijing 101408, China.
Viruses. 2024 Apr 18;16(4):631. doi: 10.3390/v16040631.
is the largest and most diverse genus in the family Peribunyaviridae. Orthobunyaviruses are widely distributed globally and pose threats to human and animal health. Ebinur Lake virus (EBIV) is a newly classified Orthobunyavirus detected in China, Russia, and Kenya. This study explored the antiviral effects of two broad-spectrum antiviral drugs, favipiravir and ribavirin, in a BALB/c mouse model. Favipiravir significantly improved the clinical symptoms of infected mice, reduced viral titer and RNA copies in serum, and extended overall survival. The median survival times of mice in the vehicle- and favipiravir-treated groups were 5 and 7 days, respectively. Favipiravir significantly reduced virus titers 10- to 100-fold in sera at all three time points compared to vehicle-treated mice. And favipiravir treatment effectively reduced the virus copies by approximately 10-fold across the three time points, relative to vehicle-treated mice. The findings expand the antiviral spectrum of favipiravir for orthobunyaviruses in vivo.
是布尼亚病毒科中最大且最多样化的属。正布尼亚病毒在全球广泛分布，对人类和动物健康构成威胁。艾比湖病毒（EBIV）是一种在中国、俄罗斯和肯尼亚检测到的新分类正布尼亚病毒。本研究在BALB/c小鼠模型中探讨了两种广谱抗病毒药物法匹拉韦和利巴韦林的抗病毒效果。法匹拉韦显著改善了感染小鼠的临床症状，降低了血清中的病毒滴度和RNA拷贝数，并延长了总体生存期。溶剂对照组和法匹拉韦治疗组小鼠的中位生存时间分别为5天和7天。与溶剂对照组小鼠相比，法匹拉韦在所有三个时间点均使血清中的病毒滴度显著降低了10至100倍。并且与溶剂对照组小鼠相比，法匹拉韦治疗在三个时间点均有效地将病毒拷贝数降低了约10倍。这些发现扩展了法匹拉韦在体内对正布尼亚病毒的抗病毒谱。
