XMEA：一种用于原位评估纳米颗粒增强辐射剂量的新型混合金刚石多电极阵列

XMEA: A New Hybrid Diamond Multielectrode Array for the In Situ Assessment of the Radiation Dose Enhancement by Nanoparticles.

作者信息

Nicolucci Patricia, Gambaro Guilherme, Araujo Silva Kyssylla Monnyelle, Souza Lima Iara, Baffa Oswaldo, Pasquarelli Alberto

机构信息

Department of Physics, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-901, Brazil.

Institute of Electron Devices and Circuits, University of Ulm, 89069 Ulm, Germany.

出版信息

Sensors (Basel). 2024 Apr 10;24(8):2409. doi: 10.3390/s24082409.

DOI:10.3390/s24082409

PMID:38676026

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11053603/

Abstract

This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-crystal diamond divided into four quadrants for X-ray dosimetry. DEF was assessed in water solutions with up to a 1000 µg/mL concentration of silver, platinum, and gold nanoparticles. The X-ray detectors showed a linear response to radiation dose (r ≥ 0.9999). Overall, platinum and gold nanoparticles produced a dose enhancement in the medium (maximum of 1.9 and 3.1, respectively), while silver nanoparticles produced a shielding effect (maximum of 37%), lowering the dose in the medium. This work shows that the novel MEA can be a useful tool in the quantitative assessment of radiation dose enhancement due to nanoparticles. Together with its suitability for cells' exocytosis studies, it proves to be a highly versatile device for several applications.

摘要

这项工作展示了一种新型多电极阵列（MEA），用于定量评估嵌入纳米颗粒在介质中产生的剂量增强因子（DEF）。该MEA有16个纳米晶金刚石电极（在细胞培养孔中），还有一个分为四个象限用于X射线剂量测定的单晶金刚石。在银、铂和金纳米颗粒浓度高达1000 µg/mL的水溶液中评估了DEF。X射线探测器对辐射剂量呈线性响应（r≥0.9999）。总体而言，铂和金纳米颗粒在介质中产生了剂量增强（分别最大为1.9和3.1），而银纳米颗粒产生了屏蔽效应（最大为37%），降低了介质中的剂量。这项工作表明，新型MEA可成为定量评估纳米颗粒引起的辐射剂量增强的有用工具。连同其适用于细胞胞吐作用研究，它被证明是一种适用于多种应用的高度通用的设备。