Alfred Health Radiation Oncology, The Alfred, Commercial Road, Melbourne, Victoria 3004, Australia.
School of Science, RMIT University, La Trobe Street, Melbourne, Victoria 3000, Australia.
J Synchrotron Radiat. 2020 Nov 1;27(Pt 6):1590-1600. doi: 10.1107/S1600577520012849. Epub 2020 Oct 23.
The physical absorbed dose enhancement by the inclusion of gold and bismuth nanoparticles fabricated into water-equivalent PRESAGE dosimeters was investigated. Nanoparticle-loaded water-equivalent PRESAGE dosimeters were irradiated with superficial, synchrotron and megavoltage X-ray beams. The change in optical density of the dosimeters was measured using UV-Vis spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose enhancement was measured for 5 nm and 50 nm monodispersed gold nanoparticles, 5-50 nm polydispersed bismuth nanoparticles, and 80 nm monodispersed bismuth nanoparticles at concentrations from 0.25 mM to 2 mM. The dose enhancement was highest for the 95.3 keV mean energy synchrotron beam (16-32%) followed by the 150 kVp superficial beam (12-21%) then the 6 MV beam (2-5%). The bismuth nanoparticle-loaded dosimeters produced a larger dose enhancement than the gold nanoparticle-loaded dosimeters in the synchrotron beam for the same concentration. For the superficial and megavoltage beams the dose enhancement was similar for both species of nanoparticles. The dose enhancement increased with nanoparticle concentration in the dosimeters; however, there was no observed nanoparticle size dependence on the dose enhancement.
研究了将金和铋纳米粒子纳入水当量 PRESAGE 剂量计中对吸收剂量的增强作用。用表面、同步加速器和兆伏 X 射线照射载有纳米粒子的水当量 PRESAGE 剂量计。用 630nm 的波长在辐照前后使用紫外-可见分光光度法测量剂量计的光密度变化。测量了浓度为 0.25mM 至 2mM 的 5nm 和 50nm 单分散金纳米粒子、5-50nm 多分散铋纳米粒子和 80nm 单分散铋纳米粒子的剂量增强。95.3keV 平均能量同步加速器束的剂量增强最高（16-32%），其次是 150kVp 表面束（12-21%），然后是 6MV 束（2-5%）。对于相同浓度的同步加速器束，载铋纳米粒子的剂量计产生的剂量增强大于载金纳米粒子的剂量计。对于表面和兆伏射线，两种纳米粒子的剂量增强相似。剂量增强随剂量计中纳米粒子的浓度增加而增加；然而，没有观察到纳米颗粒尺寸对剂量增强的依赖性。
