运动表观遗传学由细胞生物能量学驱动：对大脑可塑性和认知的支持作用。
Exercise epigenetics is fueled by cell bioenergetics: Supporting role on brain plasticity and cognition.
机构信息
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Neurosurgery, UCLA Brain Injury Research Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
出版信息
Free Radic Biol Med. 2024 Aug 1;220:43-55. doi: 10.1016/j.freeradbiomed.2024.04.237. Epub 2024 Apr 25.
Exercise has the unique aptitude to benefit overall health of body and brain. Evidence indicates that the effects of exercise can be saved in the epigenome for considerable time to elevate the threshold for various diseases. The action of exercise on epigenetic regulation seems central to building an "epigenetic memory" to influence long-term brain function and behavior. As an intrinsic bioenergetic process, exercise engages the function of the mitochondria and redox pathways to impinge upon molecular mechanisms that regulate synaptic plasticity and learning and memory. We discuss how the action of exercise uses mechanisms of bioenergetics to support a "epigenetic memory" with long-term implications for neural and behavioral plasticity. This information is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders.
运动具有独特的优势，可以促进身心健康。有证据表明，运动的效果可以在相当长的一段时间内被保存到表观基因组中，从而提高各种疾病的阈值。运动对表观遗传调控的作用似乎是建立“表观遗传记忆”以影响大脑长期功能和行为的核心。作为一种内在的生物能量过程，运动参与了线粒体和氧化还原途径的功能，从而影响调节突触可塑性和学习记忆的分子机制。我们讨论了运动的作用如何利用生物能量学的机制来支持“表观遗传记忆”，这对神经和行为可塑性具有长期影响。这些信息对于指导运动的力量减轻神经和精神疾病的负担至关重要。
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