Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Fla.
Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Fla.
J Allergy Clin Immunol Pract. 2024 Jun;12(6):1472-1478. doi: 10.1016/j.jaip.2024.04.030. Epub 2024 Apr 26.
Postnasal drip (PND) is a common symptom encountered when evaluating subjects with sinonasal disease; it may be present without sinonasal disease or as a symptom of laryngopharyngeal reflux. It is postulated that PND stems from dysfunction of normal mucus clearance mechanisms; however, there is no definitive evidence elucidating an exact pathophysiology. Compounding the uncertainties surrounding PND is the lack of an objective assessment tool. Instead, treating physicians must rely on subjective complaints and investigators utilize validated patient-reported outcome instruments, such as the Sino-Nasal Outcome Test, to determine treatment efficacy. This review seeks to discuss the current understanding of PND and evidence regarding effective treatment strategies.
鼻后滴注（PND）是评估鼻-鼻窦疾病患者时常见的症状；它可能在没有鼻-鼻窦疾病的情况下存在，也可能是喉咽反流的症状。据推测，PND 源于正常黏液清除机制的功能障碍；然而，目前还没有明确的证据阐明确切的病理生理学。使 PND 周围的不确定性更加复杂的是缺乏客观评估工具。相反，治疗医生必须依靠主观抱怨，研究人员则利用经过验证的患者报告结果工具，如鼻-鼻窦结局测试，来确定治疗效果。本综述旨在讨论目前对 PND 的理解以及关于有效治疗策略的证据。
