Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Int J Biol Macromol. 2024 May;268(Pt 2):131871. doi: 10.1016/j.ijbiomac.2024.131871. Epub 2024 Apr 25.
Multifunctional hydrogels have been developed to meet the various requirements of wound healing. Herein, an innovative hydrogel (QCMC-HA-PEG) was formed through the Schiff base reaction, composed of quaternary ammonium-modified carboxymethyl chitosan (QCMC), hyaluronic acid (HA), and 8-arms Polyethylene Glycol aldehyde (8-ARM-PEG-CHO). The resulting hydrogels exhibited good mechanical and adhesive properties with improved antibacterial efficacy against both Gram-positive and Gram-negative bacteria compared to CMC hydrogels. QCMC-HA-PEG hydrogels demonstrated remarkable adhesive ability in lap-shear test. Furthermore, the incorporation of MnO nanosheets into the hydrogel significantly enhanced its reactive oxygen species (ROS) scavenging and oxygen generation capabilities. Finally, experimental results from a full-thickness skin wound model revealed that the QCMC-HA-PEG@MnO hydrogel promoted skin epithelization, collagen deposition, and inflammatory regulation significantly accelerated the wound healing process. Therefore, QCMC-HA-PEG@MnO hydrogel could be a promising wound dressing to promote wound healing.
多功能水凝胶的发展满足了伤口愈合的各种要求。本文通过席夫碱反应形成了一种创新的水凝胶（QCMC-HA-PEG），由季铵化羧甲基壳聚糖（QCMC）、透明质酸（HA）和 8 臂聚乙二醇醛（8-ARM-PEG-CHO）组成。与 CMC 水凝胶相比，所得水凝胶具有良好的机械和粘附性能，对革兰氏阳性菌和革兰氏阴性菌的抗菌效果均得到改善。QCMC-HA-PEG 水凝胶在搭接剪切试验中表现出优异的粘附能力。此外，将 MnO 纳米片掺入水凝胶中显著提高了其活性氧物质（ROS）清除和氧气生成能力。最后，全厚度皮肤创面模型的实验结果表明，QCMC-HA-PEG@MnO 水凝胶显著促进皮肤上皮化、胶原沉积和炎症调节，显著加速了伤口愈合过程。因此，QCMC-HA-PEG@MnO 水凝胶可能是一种有前途的伤口敷料，可促进伤口愈合。
