LEPABE, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE-Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
LEPABE, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE-Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Int J Biol Macromol. 2024 Jun;269(Pt 1):131792. doi: 10.1016/j.ijbiomac.2024.131792. Epub 2024 Apr 25.
Vitamin E encapsulation into biopolymer-based microparticles, obtained by spray-drying technology, was proposed to improve the encapsulation efficiency and the controlled release of fat-soluble vitamin. Binary and ternary blends of pectin, modified chitosan and modified starch, modified starch + modified chitosan, modified starch + pectin, modified chitosan + pectin and modified starch + modified chitosan + pectin ((0.33, 0.33, 0.33), (0.70, 0.15, 0.15), (0.15, 0.70, 0.15) and (0.15, 0.15, 0.70)) were proposed to produce and evaluate different carrier-based delivery systems. Vitamin E-loaded microparticles and empty microparticles were created with a product yield between 9 and 49 %. The mean diameter among all microparticles varied between 3.74 ± 0.02 and 421 ± 21 μm (differential volume distribution). Oval, spherical or irregular microparticles, with a variable morphology from a smooth to a high rough surface structure, with concavities, were produced. All vitamin E-loaded microparticles exhibited an encapsulation efficiency higher than 70 %. The slower vitamin E controlled release was observed from microparticles composed by modified chitosan (>36 h), while the faster release was achieved from microparticles individually composed by pectin (39 min). In general, the Fickian diffusion is the main release mechanism involved in the microparticles produced with modified chitosan, other formulations combine also other mechanisms such as swelling.
将维生素 E 包封到基于生物聚合物的微球中，通过喷雾干燥技术获得，旨在提高脂溶性维生素的包封效率和控制释放。果胶、改性壳聚糖和改性淀粉的二元和三元混合物、改性淀粉+改性壳聚糖、改性淀粉+果胶、改性壳聚糖+果胶和改性淀粉+改性壳聚糖+果胶（(0.33, 0.33, 0.33)、(0.70, 0.15, 0.15)、(0.15, 0.70, 0.15) 和 (0.15, 0.15, 0.70)) 被提议用于生产和评估不同的基于载体的递药系统。用产物产率在 9%至 49%之间制备和评价了载有维生素 E 的微球和空微球。所有微球的平均粒径在 3.74±0.02 和 421±21 μm 之间变化（微分体积分布）。制备了具有可变形态的椭圆形、球形或不规则微球，其表面结构从光滑到高粗糙，具有凹陷。所有载有维生素 E 的微球的包封效率均高于 70%。由改性壳聚糖组成的微球中维生素 E 的释放速度较慢（>36 小时），而由果胶单独组成的微球的释放速度较快（39 分钟）。通常，Fickian 扩散是涉及由改性壳聚糖制成的微球的主要释放机制，其他配方还结合了其他机制，如溶胀。
