2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Photodiagnosis Photodyn Ther. 2024 Jun;47:104095. doi: 10.1016/j.pdpdt.2024.104095. Epub 2024 Apr 27.
To investigate changes in choroidal thickness in patients diagnosed with pseudoexfoliation syndrome (PEX) compared to healthy controls, using optical coherence tomography (OCT).
PubMed and Scopus databases were systematically searched for published articles comparing choroidal thickness between patients with PEX and healthy controls. Standardized Mean Difference (SMD) with 95 % confidence interval (CI) was computed to compare continuous variables. Revman 5.4 was used for the analysis. Subgroup analyses were performed according to OCT devices used.
12 studies were included in our analysis. Subfoveal choroidal thickness was decreased in patients with PEX compared to healthy controls. Subgroup analysis confirmed this finding in studies that used Heidelberg or Optovue OCT Devices.
Our meta-analysis showed that choroidal thickness was decreased in patients with PEX compared to controls. Increased heterogeneity and small case-control studies are the main limitations of the meta-analysis. Further studies are needed to evaluate the clinical significance of reduced subfoveal choroidal thickness in PEX.
使用光学相干断层扫描（OCT）研究诊断为假性剥脱综合征（PEX）患者与健康对照组相比脉络膜厚度的变化。
系统检索 PubMed 和 Scopus 数据库中比较 PEX 患者与健康对照组之间脉络膜厚度的已发表文章。使用标准化均数差（SMD）和 95%置信区间（CI）来比较连续变量。使用 Revman 5.4 进行分析。根据使用的 OCT 设备进行亚组分析。
本分析纳入了 12 项研究。与健康对照组相比，PEX 患者的中心凹下脉络膜厚度降低。亚组分析证实了海德堡或 Optovue OCT 设备研究中的这一发现。
我们的荟萃分析显示，与对照组相比，PEX 患者的脉络膜厚度降低。异质性增加和小病例对照研究是荟萃分析的主要局限性。需要进一步研究来评估 PEX 患者中心凹下脉络膜厚度降低的临床意义。
