State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
ChemMedChem. 2024 Aug 1;19(15):e202400227. doi: 10.1002/cmdc.202400227. Epub 2024 Jun 1.
Molecular optical probes play pivotal roles in in vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine-based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near-infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing mechanisms are discussed along with applications in the detection of renal cell carcinoma and acute kidney injury. This progress provides insights and directions for the development of next generation kidney-targeted probes and for pushing their further applications in preclinical and clinical research.
分子光学探针在与肾脏疾病相关的生物标志物的活体成像中发挥着关键作用。近年来，基于菁或半菁骨架的结构可调性和高光荧光量子产率，构建了多种光学探针。本综述总结了用于肾脏疾病成像的光学探针的最新进展，特别是通过近红外荧光、化学发光和光声成像模式。讨论了化学设计和传感机制以及在检测肾细胞癌和急性肾损伤中的应用。这一进展为开发下一代肾脏靶向探针提供了思路和方向，并推动了它们在临床前和临床研究中的进一步应用。
