饮酒与中老年人群生物年龄加速老化：来自两个队列的纵向研究。

Alcohol consumption and accelerated biological ageing in middle-aged and older people: A longitudinal study from two cohorts.

机构信息

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

School of Public Health, Kunming Medical University, Kunming, China.

出版信息

Addiction. 2024 Aug;119(8):1387-1399. doi: 10.1111/add.16501. Epub 2024 Apr 28.

DOI:10.1111/add.16501

PMID:38679855

Abstract

BACKGROUND AND AIMS

The relationship between alcohol consumption and age-related diseases is inconsistent. Biological age (BA) serves as both a precursor and a predictor of age-related diseases; however, longitudinal associations between alcohol consumption and BA in middle-aged and older people remain unclear. We measured whether there was a longitudinal association between drinking frequency and pure alcohol intake with BA among middle-aged and older people.

DESIGN AND SETTING AND PARTICIPANTS

This study involved two prospective cohort studies, set in Southwestern China and the United Kingdom. A total of 8046 participants from the China Multi-Ethnic Cohort study (CMEC) and 5412 participants from the UK Biobank (UKB), aged 30-79 years, took part, with complete data from two waves of clinical biomarkers.

MEASUREMENTS

BA was calculated by the Klemera Doubal's method. Accelerated BA equalled BA minus chronological age. Drinking frequency and pure alcohol intake were obtained through self-reported questionnaires. Drinking frequency in the past year was classified as current non-drinking, occasional (monthly drinking) and regular (weekly drinking).

FINDINGS

Compared with consistent current non-drinkers, more frequent drinkers [CMEC: β = 0.46, 95% confidence interval (CI) = 0.13-0.80; UKB: β = 0.65, 95% CI = 0.01-1.29)], less frequent drinkers (CMEC: β = 0.62, 95% CI = 0.37-0.87; UKB: β = 0.54, 95% CI = -0.01-1.09), consistent occasional drinkers (CMEC: β = 0.51, 95% CI = 0.23-0.79; UKB: β = 0.63, 95% CI = 0.13-1.13) and consistent regular drinkers (CMEC: β = 0.56, 95% CI = 0.17-0.95; UKB: β = 0.46, 95% CI = 0.00-0.91) exhibited increased accelerated BA. A non-linear relationship between pure alcohol intake and accelerated BA was observed among consistent regular drinkers.

CONCLUSIONS

In middle-aged and older people, any change in drinking frequency and any amount of pure alcohol intake seem to be positively associated with acceleration of biological ageing, compared with maintaining abstinence.

摘要

背景与目的

饮酒与年龄相关疾病之间的关系并不一致。生物年龄（BA）既是年龄相关疾病的前兆，也是其预测指标；然而，中年和老年人中饮酒与 BA 之间的纵向关联尚不清楚。我们旨在测量中年和老年人中饮酒频率和纯酒精摄入量与 BA 之间是否存在纵向关联。

设计、地点和参与者：本研究涉及两项前瞻性队列研究，分别在中国西南部和英国进行。来自中国多民族队列研究（CMEC）的 8046 名参与者和来自英国生物银行（UKB）的 5412 名参与者年龄在 30-79 岁之间，他们均完成了两次临床生物标志物的随访。

测量

BA 通过 Klemera Doubal 方法计算。加速 BA 等于 BA 减去实际年龄。饮酒频率和纯酒精摄入量通过自我报告的问卷获得。过去一年的饮酒频率分为当前非饮酒者、偶尔饮酒者（每月饮酒）和规律饮酒者（每周饮酒）。

结果

与持续的当前非饮酒者相比，饮酒更频繁的人[CMEC：β=0.46，95%置信区间（CI）=0.13-0.80；UKB：β=0.65，95%CI=0.01-1.29]、饮酒较少的人（CMEC：β=0.62，95%CI=0.37-0.87；UKB：β=0.54，95%CI=-0.01-1.09）、持续偶尔饮酒者（CMEC：β=0.51，95%CI=0.23-0.79；UKB：β=0.63，95%CI=0.13-1.13）和持续规律饮酒者（CMEC：β=0.56，95%CI=0.17-0.95；UKB：β=0.46，95%CI=0.00-0.91）的加速 BA 更高。在持续规律饮酒者中，纯酒精摄入量与加速 BA 之间存在非线性关系。