Dizier M H, Deschamps I, Hors J, Blanc M, Rivat-Peran L, Feingold N, Clerget-Darpoux F
Rev Epidemiol Sante Publique. 1985;33(4-5):337-40.
It is now well established that HLA system is involved in the susceptibility to Type 1 diabetes mellitus. In this study we look for a possible effect of the Gm system. A first study (cases-controls) suggests that among individuals who had HLA-DR3 but not HLA-DR4 or HLA-DR4 without HLA-DR3, there is a possible effect of the phenotype Gm3,23,5 or Gm3,-5 in the susceptibility to IDDM. Moreover, we have tested by the sibpair method whether HLA and Gm are transmitted independently from IDDM: an unaffected sib, sharing the same HLA haplotypes than an affected individual, seems to be more often phenotypically different at the Gm loci.
现已充分证实，HLA系统与1型糖尿病易感性有关。在本研究中，我们探寻Gm系统可能产生的影响。第一项研究（病例对照研究）表明，在具有HLA - DR3但无HLA - DR4的个体，或具有HLA - DR4但无HLA - DR3的个体中，Gm3,23,5或Gm3,-5表型可能对胰岛素依赖型糖尿病易感性产生影响。此外，我们通过同胞对法检测了HLA和Gm是否独立于胰岛素依赖型糖尿病进行遗传传递：与患病个体共享相同HLA单倍型的未患病同胞，在Gm位点的表型差异似乎更为常见。
