胰岛素依赖型糖尿病中HLA与IgG重链同种异型之间缺乏相互作用。

Lack of interaction of HLA and IgG heavy chain allotypes in insulin-dependent diabetes mellitus.

作者信息

Sheehy M J, Meske L M, Embling M, Berkaw M, Rowe J R, Pandey J P

机构信息

American Red Cross Blood Services, Madison, Wisc.

出版信息

Exp Clin Immunogenet. 1989;6(4):269-74.

PMID:2488686

Abstract

Because of conflicting previous reports showing the presence or absence of Gm-HLA interaction in insulin-dependent diabetes mellitus (IDDM), we report results for a group of Wisconsin families having 2 or more siblings with IDDM. Although this study is very similar to one by Field et al., who found HLA-Gm interaction in IDDM, we find no evidence for such an interactive effect p = 0.33). We discuss published data on HLA-Gm interaction in IDDM, and conclude that overall there is little reason to postulate such an interaction.

摘要

由于先前相互矛盾的报告显示胰岛素依赖型糖尿病（IDDM）中存在或不存在Gm-HLA相互作用，我们报告了一组有两个或更多患IDDM兄弟姐妹的威斯康星州家庭的研究结果。尽管本研究与Field等人的研究非常相似，他们在IDDM中发现了HLA-Gm相互作用，但我们没有发现这种相互作用效应的证据（p = 0.33）。我们讨论了已发表的关于IDDM中HLA-Gm相互作用的数据，并得出结论，总体而言几乎没有理由假定存在这种相互作用。