Jia Haijiao, Cheng Mengqi, Zhao Ran, Zheng Pingyi, Ren Fangfang, Nan Yaqin, Huang Mengting, Li Youxin
Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
ACS Omega. 2024 Apr 10;9(16):17817-17831. doi: 10.1021/acsomega.3c07133. eCollection 2024 Apr 23.
An effective palladium nanocatalyst (FeO@SiO-FPBA-DTPA-Pd) was proposed and prepared, which was immobilized on magnetic silica with ethylenediamine pentaacetic acid and formylphenylboronic acid as biligands. A series of characterizations showed that FeO@SiO-FPBA-DTPA-Pd was 5-15 nm and contained 1.44 mmol/g Pd/Pd. It was stable below 232.7 °C, and its saturation magnetization value was 21.17 emu/g which was easily recycled by a magnet. Its catalytic ability was evaluated through 7 Suzuki reactions and 15 Heck reactions. Results showed that the yields of 14 reactions catalyzed by FeO@SiO-FPBA-DTPA-Pd were more than 90%, while were better than those of the other two immobilized Pd catalysts on a single diethyltriamine pentaacetic acid (DTPA) group or boronic acid group. Moreover, FeO@SiO-FPBA-DTPA-Pd showed good reusability in both Suzuki and Heck reactions. In two model Suzuki and Heck reactions, after seven cycles, its yields were still above 95% without significant loss, which exceeded those of many reported catalysts; therefore, it has great potential in future large-scale industrial production.
一种有效的钯纳米催化剂（FeO@SiO-FPBA-DTPA-Pd）被提出并制备，它以乙二胺五乙酸和甲酰基苯硼酸作为双配体固定在磁性二氧化硅上。一系列表征表明，FeO@SiO-FPBA-DTPA-Pd粒径为5-15纳米，含钯量为1.44 mmol/g Pd/Pd。它在232.7℃以下稳定，其饱和磁化强度值为21.17 emu/g，可通过磁铁轻松回收。通过7个铃木反应和15个赫克反应评估了其催化能力。结果表明，FeO@SiO-FPBA-DTPA-Pd催化的14个反应产率超过90%，优于另外两种分别以单乙二胺五乙酸（DTPA）基团或硼酸基团固定的钯催化剂。此外，FeO@SiO-FPBA-DTPA-Pd在铃木反应和赫克反应中均表现出良好的可重复使用性。在两个铃木和赫克反应模型中，经过7个循环后，其产率仍高于95%，且无明显损失，超过了许多已报道的催化剂；因此，它在未来大规模工业生产中具有巨大潜力。
