线粒体钙通量——慢性心力衰竭中的朋友还是敌人？ - Suppr

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超能文献

Mitochondrial Calcium Flux-Friend or Foe in Chronic Heart Failure?

作者信息

Niemi Natalie M

机构信息

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri, USA.

出版信息

JACC Basic Transl Sci. 2024 Apr 22;9(4):519-521. doi: 10.1016/j.jacbts.2024.02.018. eCollection 2024 Apr.

DOI:10.1016/j.jacbts.2024.02.018

PMID:38680964

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11055213/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44e6/11055213/1438e6da6968/ga1.jpg

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本文引用的文献

Mitochondrial Ca Uniporter-Dependent Energetic Dysfunction Drives Hypertrophy in Heart Failure.线粒体钙单向转运体依赖性能量功能障碍驱动心力衰竭中的心肌肥大。

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Hypocalcemia as a cause of reversible heart failure: A case report and review of the literature.低钙血症作为可逆性心力衰竭的病因：一例病例报告及文献综述

Ann Med Surg (Lond). 2022 Apr 5;77:103572. doi: 10.1016/j.amsu.2022.103572. eCollection 2022 May.

Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.鉴定和功能验证 FDA 批准的线粒体钙单向转运体的正向和负向调节剂。

Cell Rep. 2021 Jun 22;35(12):109275. doi: 10.1016/j.celrep.2021.109275.

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca Leak.MCU 过表达通过减少 SR Ca 渗漏来挽救心肌收缩力并逆转心力衰竭。

Circ Res. 2021 Apr 16;128(8):1191-1204. doi: 10.1161/CIRCRESAHA.120.318562. Epub 2021 Feb 1.

Int J Cardiol. 2018 Nov 15;271:161-168. doi: 10.1016/j.ijcard.2018.05.054. Epub 2018 May 20.

Mitochondrial calcium overload is a key determinant in heart failure.线粒体钙超载是心力衰竭的关键决定因素。

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11389-94. doi: 10.1073/pnas.1513047112. Epub 2015 Jul 27.

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.一种四十千道尔顿的内膜蛋白是线粒体钙单向转运蛋白。

Nature. 2011 Jun 19;476(7360):336-40. doi: 10.1038/nature10230.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.整合基因组学鉴定 MCU 为线粒体钙单向转运体的必需组成部分。

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.

Regulation of mitochondrial dehydrogenases by calcium ions.钙离子对线粒体脱氢酶的调节作用。

Biochim Biophys Acta. 2009 Nov;1787(11):1309-16. doi: 10.1016/j.bbabio.2009.01.005. Epub 2009 Jan 20.

Calcium uptake by rat kidney mitochondria.大鼠肾线粒体对钙的摄取

Proc Natl Acad Sci U S A. 1961 Nov 15;47(11):1744-50. doi: 10.1073/pnas.47.11.1744.

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