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妊娠期无症状菌尿的临床微生物学特征及结局

Clinico-microbiological Profile and Outcomes of Asymptomatic Bacteriuria in Pregnancy.

作者信息

Eshwarappa Mahesh, Rao Medha Y, Kc Gurudev, Ms Gireesh, Swaroop Asha, Suryadevara Saritha

机构信息

Department of Nephrology, M S Ramaiah Medical College, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.

Department of General Medicine, M S Ramaiah Medical College, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.

出版信息

Indian J Nephrol. 2024 Mar-Apr;34(2):134-138. doi: 10.4103/ijn.ijn_305_21. Epub 2023 Sep 29.

Abstract

BACKGROUND

Asymptomatic bacteriuria (ASB) during pregnancy can lead to symptomatic urinary tract infection (UTI), with increased fetal and maternal morbidity and mortality. We evaluated the incidence, clinical and microbiological profile, and outcome of ASB in pregnant women attending our antenatal clinic.

MATERIALS AND METHODS

This prospective study was conducted on 3769 pregnant women in a routine antenatal clinic at a tertiary care center. Participants were divided into two groups, ASB and non-bacteriuria. Data were collected in a standard proforma and analyzed using the software Statistical Package for the Social Sciences (SPSS) v. 20.

RESULTS

The incidence of ASB was 3.29% (124/3769). Majority of the women were in the age group of 21-30 years (78.76%, = 89). (61.06%) was the most common organism isolated. Maternal anemia (30.08% and 2.93% in the ASB and non-bacteriuria groups, respectively), low birth weight (LBW; 42.5% and 27.98% in the ASB and non-bacteriuria groups, respectively), intrauterine death (4.4% and 1.4% in the ASB and non-bacteriuria groups, respectively), and preterm delivery (37.2% and 22.31% in the ASB and non-bacteriuria groups, respectively) were were associated with ASB ( = 0.001).

CONCLUSION

ASB was associated with maternal anemia, preterm delivery, intrauterine death, and LBW. Early detection and treatment of ASB may result in favorable maternal outcome.

摘要

背景

孕期无症状菌尿(ASB)可导致有症状的尿路感染(UTI),增加胎儿和母亲的发病率及死亡率。我们评估了在我们产前诊所就诊的孕妇中ASB的发病率、临床和微生物学特征以及结局。

材料与方法

这项前瞻性研究在一家三级医疗中心的常规产前诊所对3769名孕妇进行。参与者被分为两组,ASB组和无菌尿组。数据通过标准表格收集,并使用社会科学统计软件包(SPSS)v.20进行分析。

结果

ASB的发病率为3.29%(124/3769)。大多数女性年龄在21 - 30岁组(78.76%,n = 89)。大肠埃希菌(61.06%)是最常分离出的病原体。母亲贫血(ASB组和无菌尿组分别为30.08%和2.93%)、低出生体重(LBW;ASB组和无菌尿组分别为42.5%和27.98%)、宫内死亡(ASB组和无菌尿组分别为4.4%和1.4%)以及早产(ASB组和无菌尿组分别为37.2%和22.31%)均与ASB相关(P = 0.001)。

结论

ASB与母亲贫血、早产、宫内死亡和低出生体重相关。早期检测和治疗ASB可能会带来良好的母亲结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd69/11044665/4544b8de92e4/IJN-34-2-134-g1.jpg

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