Celen Sevki, Oruç Ayla Sargin, Karayalçin Rana, Saygan Sibel, Unlü Serpil, Polat Belgin, Danişman Nuri
Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara 06230, Turkey.
ISRN Obstet Gynecol. 2011;2011:721872. doi: 10.5402/2011/721872. Epub 2011 Jan 24.
Introduction. Asymptomatic bacteriuria (ASB), occurring in 2-11% of pregnancies, is a major predisposition to the development of pyelonephritis, which is associated with obstetrical complications, such as preterm labor and low birth weight infants. The aim of this study was to determine the prevalence of ASB, the antibacterial susceptibilities of the isolated microorganisms and the associated risk factors in an outpatient clinical setting in Zekai Tahir Burak Women's Health Education and Research Hospital in Ankara, Turkey. Material and Methods. Between December 2009 and May 2010, pregnant women admitted to the antenatal outpatient clinic were included in this study. The results of a complete urine analysis, midstream urine culture and antibacterial susceptibility were evaluated. Results. Of the 2011 pregnant women included, 171 had ASB (8.5%). E. coli was the most frequently isolated microorganism (76.6%), followed by Klebsiella pneumonia (14.6%). Both microorganisms were highly sensitive to fosfomycin, sensivity being 99.2% for E. coli and 88% for Klebsiella pneumonia. Conclusions. In this certain geographical region, we found E. coli as the most common causative agent of ASB in the obstetric population and it is very sensitive to fosfomycin. We recommend fosfomycin for ASB in pregnant women due to its high sensitivity, ease of administration and safety for use in pregnancy.
引言。无症状菌尿（ASB）在2%至11%的孕妇中出现，是肾盂肾炎发生的主要诱因，而肾盂肾炎与早产和低体重儿等产科并发症相关。本研究的目的是确定土耳其安卡拉泽凯·塔希尔·布拉克妇女健康教育与研究医院门诊临床环境中无症状菌尿的患病率、分离出的微生物的抗菌敏感性以及相关危险因素。材料与方法。2009年12月至2010年5月期间，纳入产前门诊就诊的孕妇。对完整尿液分析、中段尿培养及抗菌敏感性结果进行评估。结果。在纳入的2011名孕妇中，171人患有无症状菌尿（8.5%）。大肠埃希菌是最常分离出的微生物（76.6%），其次是肺炎克雷伯菌（14.6%）。两种微生物对磷霉素均高度敏感，大肠埃希菌的敏感性为99.2%，肺炎克雷伯菌为88%。结论。在这个特定地理区域，我们发现大肠埃希菌是产科人群中无症状菌尿最常见的病原体，且对磷霉素非常敏感。由于磷霉素敏感性高、易于给药且孕期使用安全,我们推荐将其用于孕妇无症状菌尿的治疗。
