Department of Pharmacy, Bozhou Hospital of Anhui Medical University, 236800 Bozhou, Anhui, China.
School of Basic Medicine, Anhui Medical University, 230000 Hefei, Anhui, China.
Front Biosci (Landmark Ed). 2024 Apr 26;29(4):166. doi: 10.31083/j.fbl2904166.
The aims of this study were to evaluate the correlation between chemokine (C-X-C) ligand 7 (CXCL7) expression and glycolysis and to explore the prognostic significance of CXCL7 in colorectal cancer (CRC).
The expression of CXCL7 and lactate dehydrogenase A (LDH-A) was measured by immunohistochemistry in tissue from 158 CRC patients. Patients were divided into high expression and low expression groups based on receiver operating characteristic curves and a cut-off value. The correlation between CXCL7 and LDH-A expression was evaluated. The overall survival (OS) times of CRC patients were explored. The risk factors related to prognosis were assessed.
Significantly higher expression of CXCL7 and LDH-A was detected in CRC tissue than in non-CRC tissue, and was associated with N stage and tumor-node-metastasis (TNM) stage. CXCL7 expression was strongly correlated with LDH-A expression in CRC tissue. High expression of CXCL7 was validated as an independent risk factor for OS.
Increased expression of CXCL7 was positively correlated with LDH-A expression and was an independent risk factor for CRC prognosis.
本研究旨在评估趋化因子（C-X-C）配体 7（CXCL7）表达与糖酵解之间的相关性，并探讨 CXCL7 在结直肠癌（CRC）中的预后意义。
采用免疫组织化学法检测 158 例 CRC 患者组织中 CXCL7 和乳酸脱氢酶 A（LDH-A）的表达。根据受试者工作特征曲线和截断值将患者分为高表达组和低表达组。评估 CXCL7 与 LDH-A 表达之间的相关性。探讨 CRC 患者的总生存（OS）时间。评估与预后相关的危险因素。
CRC 组织中 CXCL7 和 LDH-A 的表达明显高于非 CRC 组织，且与 N 分期和肿瘤-淋巴结-转移（TNM）分期相关。CRC 组织中 CXCL7 表达与 LDH-A 表达呈强相关性。高表达 CXCL7 被验证为 OS 的独立危险因素。
CXCL7 表达增加与 LDH-A 表达呈正相关，是 CRC 预后的独立危险因素。
