Liu Jing, Li Yuan, Peng Li-Qing, Gao Yue, Shi Ke, Qian Wen-Lei, Yan Wei-Feng, Yang Zhi-Gang
Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
J Magn Reson Imaging. 2025 Jan;61(1):235-247. doi: 10.1002/jmri.29406. Epub 2024 Apr 29.
Metabolic syndrome (MetS) is associated with worse prognosis in patients with myocardial infarction (MI). However, it is unclear how MetS in MI patients is associated with left atrial (LA) and left ventricular (LV) deformation.
To determine the effect of MetS on LA and LV deformation and atrioventricular interactions in MI patients.
Retrospective.
One hundred eighty-one MI patients (73 MetS+ and 108 MetS-), 107 age- and sex-matched controls (49 MetS+ and 58 MetS-).
FIELD STRENGTH/SEQUENCE: 3.0 T/balanced steady-state free precession (SSFP)/segmented phase-sensitive inversion recovery SSFP sequence.
LA strain and strain rates (reservoir, conduit, and active), left atrioventricular coupling index (LACI), and LV geometry and radial, circumferential and longitudinal global peak strains (PS) were compared among groups.
Two-way analysis of variance, Spearman and Pearson's correlation coefficients, and multivariable linear regression analysis. P value <0.05 indicated statistical significance.
Compared with controls, the MI patients with or without MetS showed impaired LA function (reservoir, conduit, and active) and LV deformation (radial, circumferential, and longitudinal PS) and higher LACI. The MetS+ group had lower LA reservoir and conduit function and LV deformation than MetS- group. The MetS-MI interaction was not statistically significant. Furthermore, multivariable linear regression showed that MetS was independently associated with LA and LV deformation (β = -0.181 to -0.209) in MI patients; LA function was independently associated with LV circumferential PS (β = 0.230 to 0.394) and longitudinal PS (β = 0.189 to 0.420), and LA passive strain and strain rate were negatively associated with LV mass (β = -0.178 and -0.298).
MetS may be associated with the LA and LV dysfunction in MI patients. Impaired LV deformation and LV hypertrophy are independently associated with LA dysfunction in MI patients, and the MI patients have higher LACI than controls, suggesting atrioventricular interaction alterations.
4 TECHNICAL EFFICACY: 3.
代谢综合征（MetS）与心肌梗死（MI）患者的不良预后相关。然而，MI患者中的MetS如何与左心房（LA）和左心室（LV）变形相关尚不清楚。
确定MetS对MI患者LA和LV变形以及房室相互作用的影响。
回顾性研究。
181例MI患者（73例MetS阳性和108例MetS阴性），107例年龄和性别匹配的对照者（49例MetS阳性和58例MetS阴性）。
场强/序列：3.0 T/平衡稳态自由进动（SSFP）/分段相位敏感反转恢复SSFP序列。
比较各组之间的LA应变和应变率（储存、传导和主动）、左房室耦合指数（LACI）以及LV几何形状和径向、圆周和纵向整体峰值应变（PS）。
双向方差分析、Spearman和Pearson相关系数以及多变量线性回归分析。P值<0.05表示具有统计学意义。
与对照组相比，有或无MetS的MI患者均表现出LA功能受损（储存、传导和主动）和LV变形（径向、圆周和纵向PS）以及更高的LACI。MetS阳性组的LA储存和传导功能以及LV变形低于MetS阴性组。MetS-MI相互作用无统计学意义。此外，多变量线性回归显示，MetS与MI患者的LA和LV变形独立相关（β=-0.181至-0.209）；LA功能与LV圆周PS（β=0.230至0.394）和纵向PS（β=0.189至0.420）独立相关，并且LA被动应变和应变率与LV质量呈负相关（β=-0.178和-0.298）。
MetS可能与MI患者的LA和LV功能障碍相关。LV变形受损和LV肥厚与MI患者的LA功能障碍独立相关，并且MI患者的LACI高于对照组，提示房室相互作用改变。
4 技术疗效：3。
