Liu Xu, Wang Jing, Tong Yan, Wang Shuai
Department of Cardiology, The Second Affiliated Hospital of Shenyang Medical College, Shengyang, Liaoning, China.
Department of Social Services, Shengjing Hospital Affiliated to China Medical University, Shengyang, Liaoning, China.
Front Cardiovasc Med. 2025 Apr 10;12:1567856. doi: 10.3389/fcvm.2025.1567856. eCollection 2025.
The left atrioventricular coupling index (LACI) has emerged as a novel and transformative biomarker in cardiovascular research, addressing long-standing limitations in traditional cardiac function assessments. By quantifying the ratio of left atrial to left ventricular end-diastolic volumes, LACI offers unprecedented prognostic insights into a wide range of cardiovascular diseases, including atrial fibrillation, heart failure, and myocardial infarction, as well as other conditions such as hypertension and cardiomyopathies. Recent evidence highlights its unique ability to integrate atrial and ventricular dynamics, offering a more comprehensive perspective on cardiac health and disease progression. This review synthesizes the latest advancements in LACI research, elucidates its underlying pathophysiological mechanisms, and explores its expanding clinical applications as a pivotal tool for risk stratification, precision diagnostics, and personalized therapy in cardiovascular medicine.
左房室耦合指数（LACI）已成为心血管研究中一种新颖且具有变革性的生物标志物，解决了传统心功能评估中长期存在的局限性。通过量化左心房与左心室舒张末期容积之比，LACI为包括心房颤动、心力衰竭、心肌梗死以及高血压和心肌病等其他病症在内的多种心血管疾病提供了前所未有的预后见解。最近的证据凸显了其整合心房和心室动力学的独特能力，为心脏健康和疾病进展提供了更全面的视角。本综述综合了LACI研究的最新进展，阐明了其潜在的病理生理机制，并探讨了其作为心血管医学中风险分层、精准诊断和个性化治疗的关键工具不断扩展的临床应用。
