Department of Genetic Engineering, School of Bioengineering, College of Engineering & Technology, SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
Future Microbiol. 2024 Jul 2;19(10):941-961. doi: 10.2217/fmb-2023-0263. Epub 2024 Apr 29.
A higher prevalence of infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.
最近有报道称，医院获得性感染（HAI）中 的感染率和死亡率较高。 的生物膜形成能力使其成为一种极其危险的病原体，特别是在与设备相关的医院获得性感染（DA-HAI）中，从而使其能够抵抗抗生素的渗透。此外，在疫情期间，DA-HAI 中 SARS-CoV-2 病毒的传播加剧。本综述专门研究了在生物膜形成和感染发展中起作用的几个成分和基因之间的复杂相互关系。本综述提供了对抗 生物膜相关感染的创新治疗和治疗方法的见解，从而最终改善患者的预后并减轻 HAI 的负担。
