Martin Julien, Lübke Jan
Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Kilianstr. 5, 79106, Freiburg, Deutschland.
Ophthalmologie. 2024 May;121(5):427-437. doi: 10.1007/s00347-024-02041-5. Epub 2024 Apr 29.
Excessive wound healing in filtering glaucoma surgery is a key factor for a failed surgery. After the introduction of trabeculectomy in the 1960s many factors associated with an increased fibrotic reaction were recognized and methods were developed to influence postoperative wound healing. These range from the perioperative use of anti-inflammatory drugs and antimetabolites to the use of newer chemical compounds that influence the morphology of postoperative fibroblast growth. In the routine clinical practice, the fine tuning of therapeutic decisions plays a decisive role in the success or failure of filtration surgery.
滤过性青光眼手术中过度的伤口愈合是手术失败的关键因素。自20世纪60年代小梁切除术问世以来,人们认识到许多与纤维化反应增加相关的因素,并开发了一些方法来影响术后伤口愈合。这些方法包括围手术期使用抗炎药物和抗代谢药物,以及使用影响术后成纤维细胞生长形态的新型化合物。在常规临床实践中,治疗决策的微调对滤过手术的成败起着决定性作用。