Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, 28 Fu Xing Road, Beijing, 100853, People's Republic of China.
College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
Ann Biomed Eng. 2024 Aug;52(8):1955-1981. doi: 10.1007/s10439-024-03523-y. Epub 2024 Apr 29.
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, many in vitro and in vivo studies have shown that LIPUS may play its anti-inflammatory role by activating signaling pathways such as integrin/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt), Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS), or inhibiting signaling pathways such as Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-κB) and p38-Mitogen-activated protein kinase (MAPK). As a non-invasive physical therapy, the anti-inflammatory and immunomodulatory effects of LIPUS deserve further exploration.
超声已从医学影像学和诊断技术领域扩展到治疗领域。低强度脉冲超声（LIPUS）是一种治疗性超声，在促进骨折愈合、伤口修复、免疫调节和减轻炎症方面发挥着重要作用。其抗炎作用表现为促炎细胞因子和趋化因子减少、免疫细胞浸润加速消退以及损伤修复加速。尽管 LIPUS 的抗炎机制尚不清楚，但许多体外和体内研究表明，LIPUS 可能通过激活整合素/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt)、Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS) 等信号通路，或抑制 Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-κB) 和 p38-Mitogen-activated protein kinase (MAPK) 等信号通路发挥抗炎作用。作为一种非侵入性的物理治疗方法，LIPUS 的抗炎和免疫调节作用值得进一步探索。
