吡唑啉酮对大鼠肝脏谷胱甘肽的影响。
Influence of pyrazolones on hepatic glutathione in rats.
作者信息
Bien E, Witt M
出版信息
Arch Toxicol Suppl. 1985;8:366-9. doi: 10.1007/978-3-642-69928-3_75.
Aminophenazone, phenazone, propyphenazone, and paracetamol given to female Wistar rats in a dose of 3 mmol/kg decrease the GSH content in the liver by 24, 18, 58, and 24 per cent, respectively. After the repeated administration (5 days) only aminophenazone depletes the hepatic GSH. The pretreatment with phenobarbital or cobaltous chloride has an influence only on the effect of propyphenazone. Hepatotoxins cause more extensive hepatotoxic alterations than the drugs investigated, however, their influence on the hepatic GSH level is negligible. Therefore it can be concluded that a temporary GSH depletion is not always linked with a hepatotoxic effect.
以3 mmol/kg的剂量给雌性Wistar大鼠注射氨基比林、非那宗、安乃近和对乙酰氨基酚，可使肝脏中谷胱甘肽（GSH）的含量分别降低24%、18%、58%和24%。重复给药（5天）后，只有氨基比林会耗尽肝脏中的GSH。用苯巴比妥或氯化钴预处理仅对对安乃近的效果有影响。然而，与所研究的药物相比，肝毒素会导致更广泛的肝毒性改变，但其对肝脏GSH水平的影响可忽略不计。因此，可以得出结论，谷胱甘肽的暂时耗竭并不总是与肝毒性作用相关。
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