Department of Orthopaedics and Traumatology, Hospital Canselor Tunku Muhriz, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak 56000 Cheras, Malaysia.
J Wound Care. 2024 May 2;33(5):298-303. doi: 10.12968/jowc.2024.33.5.298.
Activated carbon cloth (ACC), known as Zorflex dressing, has emerged as an innovative approach in managing bacterial infection in diabetic foot ulcer (DFU) treatment. This pilot study was undertaken to determine the efficacy of Zorflex ACC dressing (Chemviron Carbon Cloth Division, UK) compared to standard silver-based dressing on DFUs.
An open label, comparative, randomised controlled trial enrolling patients who attended the diabetic foot clinic was conducted between August 2022 and August 2023. The primary endpoint was a difference of 20% in wound area reduction with the ACC dressing compared to silver-based dressing within eight weeks. The secondary endpoints were proportion of complete healing, time to healing and adverse events.
The cohort comprised 40 patients. The mean wound reduction percentage at 8 weeks for patients in the ACC arm was 85.40±16.00% compared with 65.08±16.36% in the silver-based dressing arm. Complete healing was observed in six of 20 patients in the ACC arm compared to two of 20 in the silver-based dressing arm.
These data suggest that the ACC dressing promotes better ulcer healing in DFU patients than the silver-based dressing.
活性炭布（ACC），又称 Zorflex 敷料，已成为治疗糖尿病足溃疡（DFU）中细菌感染的一种创新方法。本研究旨在评估 Zorflex ACC 敷料（英国 Chemviron Carbon Cloth Division）与标准银基敷料相比在 DFU 治疗中的疗效。
在 2022 年 8 月至 2023 年 8 月期间，对参加糖尿病足诊所的患者进行了一项开放性标签、比较、随机对照试验。主要终点是在 8 周内，与银基敷料相比，ACC 敷料使创面面积减少 20%。次要终点是完全愈合的比例、愈合时间和不良事件。
该队列包括 40 名患者。ACC 组患者在 8 周时的平均创面减少百分比为 85.40±16.00%，而银基敷料组为 65.08±16.36%。在 ACC 组的 20 名患者中有 6 名完全愈合，而在银基敷料组中有 2 名。
这些数据表明，与银基敷料相比，ACC 敷料更能促进 DFU 患者溃疡的愈合。
