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昆士兰的嗜铬细胞瘤——1970 - 1983年

Phaeochromocytoma in Queensland--1970-83.

作者信息

Hartley L, Perry-Keene D

出版信息

Aust N Z J Surg. 1985 Oct;55(5):471-5.

PMID:3868411
Abstract

A statewide survey was conducted in Queensland to record all cases of phaeochromocytoma between the years of 1970 and 1983 inclusive. There were 46 cases giving an incidence of 1.55/million population per year. Twenty-nine patients (63%) were successfully treated while 10 patients (22%) died of the tumour effects. Seven cases (15%) were found incidentally at autopsy, though at least one showed diagnostic clinical features before death. Five patients (11%) had extra adrenal phaeochromocytoma, five patients (11%) had multiple tumours, four patients (9%) had multiple endocrine neoplasia and three patients (7%) had clinically malignant tumours. Of 13 patients suffering a major adrenergic crisis only six survived. Five patients with unsuspected phaeochromocytoma suffered crisis under anaesthesia and only one survived. Only one of the patients dying of benign phaeochromocytoma had adequate ante mortem adrenergic blockade. Of all patients in the series 35% were not diagnosed in life.

摘要

在昆士兰州进行了一项全州范围的调查,以记录1970年至1983年(含)期间所有嗜铬细胞瘤病例。共有46例,年发病率为每百万人口1.55例。29名患者(63%)得到成功治疗,10名患者(22%)死于肿瘤相关影响。7例(15%)在尸检时偶然发现,不过至少有1例在死前表现出诊断性临床特征。5名患者(11%)患有肾上腺外嗜铬细胞瘤,5名患者(11%)有多个肿瘤,4名患者(9%)有多发性内分泌肿瘤,3名患者(7%)有临床恶性肿瘤。13名发生严重肾上腺素能危象的患者中只有6人存活。5名未被怀疑患有嗜铬细胞瘤的患者在麻醉下发生危象,只有1人存活。死于良性嗜铬细胞瘤的患者中只有1人在死前有足够的肾上腺素能阻滞。该系列所有患者中35%生前未被诊断出来。

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