Department of Clinical Laboratory, Wuxi Ninth People's Hospital Affiliated to Soochow University, Jiangsu, China.
Wounds. 2024 Mar;36(3):73-79. doi: 10.25270/wnds/23109.
Anemia is prevalent among patients with T2DM with DFU. However, there is limited research on the relationship between Hb level and DFU.
To investigate the characteristics and relationship between Hb level and prognosis in patients with DFU.
A total of 212 patients with T2DM were included and grouped according to the presence (n = 105) or absence (n = 107) of DFU. The independent t test and multiple logistic regression analysis were used to analyze the effect of different factors on the occurrence of anemia in patients with DFU and whether Hb level could be used to predict prognosis.
There were significant differences in clinical indicators that directly or indirectly contributed to anemia in patients with DFU (P < .05). Hb level was independently associated with DFU (OR, 0.899; P < .05). Hb levels were significantly decreased in patients aged 65 years or older (P < .05). Mild anemia was prevalent among most patients with DFU (59.62%). Hb level decreased with the severity of foot ulcer (P < .05) and was correlated with the duration of diabetes (R2 = 0.653; P < .05). The AUC value was 0.82, with a cutoff value of 122.5 g/L to identify patients with DFU at high risk of adverse outcomes.
Anemia is common in patients with DFU. Anemia is a marker of DFU severity, and Hb level can predict poor prognosis in patients with DFU.
糖尿病足溃疡（DFU）患者普遍存在贫血。然而，Hb 水平与 DFU 之间的关系研究较少。
探讨 DFU 患者 Hb 水平的特征及其与预后的关系。
共纳入 212 例 T2DM 患者，根据是否存在 DFU（n=105）分为两组。采用独立 t 检验和多因素 logistic 回归分析，分析不同因素对 DFU 患者贫血发生的影响，以及 Hb 水平是否可用于预测预后。
DFU 患者贫血相关的临床指标存在显著差异（P<0.05）。Hb 水平与 DFU 独立相关（OR，0.899；P<0.05）。年龄≥65 岁的患者 Hb 水平显著降低（P<0.05）。大多数 DFU 患者存在轻度贫血（59.62%）。Hb 水平随足部溃疡严重程度而降低（P<0.05），与糖尿病病程相关（R2=0.653；P<0.05）。AUC 值为 0.82，以 122.5 g/L 作为界值可识别 DFU 患者不良结局的高危人群。
DFU 患者贫血较为常见。贫血是 DFU 严重程度的标志物，Hb 水平可预测 DFU 患者的不良预后。
