转移性透明细胞牙源性癌病例，对化疗免疫治疗有反应。
Case of metastatic clear cell odontogenic carcinoma with response to chemoimmunotherapy.
机构信息
Internal Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
Oral and Maxillofacial Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
出版信息
BMJ Case Rep. 2024 Apr 29;17(4):e259568. doi: 10.1136/bcr-2023-259568.
Our patient initially presented with 6 months of left jaw pain and gingival bleeding, leading to the discovery of a radiolucent left maxillary mass on dental evaluation. A biopsy confirmed clear cell odontogenic carcinoma, and the patient was treated with definitive surgery and radiation for localised disease. Unfortunately, the patient was found to have pulmonary metastases 3 months after initial management and was subsequently treated with a combination of cytotoxic chemotherapy and immunotherapy with a partial response. To our knowledge, this is the first case demonstrating the successful use of chemoimmunotherapy in metastatic clear cell odontogenic carcinoma.
我们的患者最初表现为 6 个月的左下颌疼痛和牙龈出血，在牙科评估时发现左侧上颌骨放射性透明肿块。活检证实为透明细胞牙源性癌，患者接受了局部疾病的根治性手术和放疗。不幸的是，患者在初始治疗后 3 个月发现肺部转移，随后接受了细胞毒性化疗和免疫治疗联合治疗，部分缓解。据我们所知，这是首例成功应用化疗免疫治疗转移性透明细胞牙源性癌的病例。
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