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水热消融治疗复发性或慢性肘滑囊炎:一项前瞻性研究。

Hydrothermal ablation in recurrent or chronic olecranon bursitis: a prospective study.

机构信息

Department of Orthopaedics, AZ Sint-Jan/Sint-Lucas Bruges, Bruges, Belgium.

Department of Orthopaedics, AZ Sint-Lucas Ghent, Ghent, Belgium.

出版信息

J Shoulder Elbow Surg. 2024 Sep;33(9):1999-2007. doi: 10.1016/j.jse.2024.03.021. Epub 2024 Apr 27.

Abstract

BACKGROUND

Olecranon bursitis can be difficult to treat, resulting in persistent or recurrent symptoms. Bursectomy is a frequently applied treatment option for refractory cases but has high complication rates. This is the first in vivo study to investigate the safety and efficacy of hydrothermal ablation, a new treatment modality for recurrent or chronic olecranon bursitis that aims to cause thermal obliteration of the bursal lining by irrigation with heated saline.

METHODS

First, a pilot animal trial was set up to determine a safe irrigation temperature window. Second, in a human trial the bursae of patients with chronic, recurrent, or refractory olecranon bursitis were irrigated with a 3-mL/s flow of physiological saline for a duration of 180 seconds at temperatures between 50°C and 52°C. Patients were followed up for 6 months, allowing for assessment of the surgical site to screen for adverse events, volumetric ultrasonographic assessment of the bursae, and collection of the Quick Disabilities of the Arm, Shoulder, and Hand questionnaire (QuickDASH), Patient Global Impression Score, and Clinical Global Impression Score, as well as data on return to activities or work.

RESULTS

Twenty-four elbows were prospectively included and underwent a full cycle of hydrothermal ablation. The mean age was 58.4 years (range 40.5-81.5), including 20 male and 4 female patients. None had clinical signs of septic bursitis. Bursal fluid cultures were positive in only 1 case. The average preoperative bursal volume was 11.18 mL (range 4.13-30.75). Eighteen of 24 elbows (75%) were successfully treated, showing a complete remission of symptoms or decided improvement within 6 weeks and without any signs of recurrence during the entire follow-up period of 6 months. The average reduction of ultrasonography-measured bursal volume was 91.9% in the group of patients who responded to treatment. In patients without recurrence, the mean QuickDASH scores before and after treatment were 13.6 (range 0-50) and 3.1 (range 0-27.5), respectively, showing a statistically significant improvement. All patients were able to fully return to work within 6 weeks after the index procedure. No serious adverse events were encountered. Moderate local adverse events were found in 2 patients. Increasing temperatures of irrigation did not result in a higher treatment efficacy.

CONCLUSION

Hydrothermal ablation at temperatures between 50°C and 52°C is a safe treatment option for recurrent or chronic olecranon bursitis with fewer complications than open bursectomy and a comparable efficacy.

摘要

背景

肘后滑囊炎的治疗较为困难,可能导致持续或反复的症状。滑囊切除术是一种常用于治疗难治性病例的方法,但并发症发生率较高。这是第一项针对复发性或慢性肘后滑囊炎的热水消融治疗的体内研究,该治疗方法旨在通过温热盐水冲洗导致滑囊衬里发生热闭塞。

方法

首先,进行了一项初步的动物试验,以确定安全的冲洗温度范围。其次,在一项人类试验中,对患有慢性、复发性或难治性肘后滑囊炎的患者,将 3 毫升/秒的生理盐水以 50°C 至 52°C 的温度持续冲洗 180 秒。患者随访 6 个月,对手术部位进行评估以筛查不良事件,对滑囊进行容积超声评估,并收集简明残疾问卷(Quick Disabilities of the Arm, Shoulder, and Hand questionnaire,QuickDASH)、患者总体印象评分(Patient Global Impression Score)和临床总体印象评分(Clinical Global Impression Score),以及活动或工作恢复的数据。

结果

前瞻性纳入 24 例肘关节炎,进行了完整的热水消融治疗周期。患者的平均年龄为 58.4 岁(范围为 40.5-81.5 岁),包括 20 名男性和 4 名女性患者。均无感染性滑囊炎的临床征象。滑液培养仅在 1 例中呈阳性。术前滑囊平均体积为 11.18 毫升(范围为 4.13-30.75 毫升)。24 例肘关节炎中,18 例(75%)成功治疗,在 6 周内症状完全缓解或明显改善,整个 6 个月的随访期间无复发迹象。对治疗有反应的患者中,超声测量的滑囊体积平均减少 91.9%。在无复发的患者中,治疗前后的 QuickDASH 评分分别为 13.6(范围为 0-50)和 3.1(范围为 0-27.5),差异具有统计学意义。所有患者在指数手术后 6 周内均能完全恢复工作。未发生严重不良事件。2 例患者出现中度局部不良事件。冲洗温度升高并未提高治疗效果。

结论

50°C 至 52°C 之间的热水消融治疗复发性或慢性肘后滑囊炎是一种安全的治疗选择,与开放性滑囊切除术相比,并发症较少,疗效相当。

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