Vyas Jigar, Raytthatha Nensi, Prajapati Bhupendra G, Singh Sudarshan
Department of Pharmaceutics, Faculty of Pharmacy, Sigma University, Vadodara, Gujarat, 390019, India.
Department of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, 382424, India.
Curr Med Chem. 2025;32(21):4176-4191. doi: 10.2174/0109298673290370240425092350.
This review explores the enhancement of therapeutic efficacy through the innovative use of polymeric molecular envelope technology (MET). It delves into the diverse methods employed to achieve superior therapeutic outcomes, shedding light on strategies for improving drug delivery and bioavailability. MET is a promising approach to improve the solubility and bioavailability of poorly water-soluble drugs. This technology involves the use of a molecular envelope of cyclic oligosaccharides called cyclodextrins, which is a supramolecular assembly of amphiphilic molecules that encapsulate and solubilize hydrophobic drug molecules. This can further improve the solubility of the drug by increasing its surface area and reducing its crystallinity. Moreover, MET also protects the drug from degradation and enhances its permeability across biological membranes. Furthermore, the review thoroughly examines the MET, including its methods of preparation, applications in drug encapsulation, and the evaluation of its potential to optimize therapeutic outcomes. By adopting current research and key findings, this review provides valuable insights into the transformative potential of polymeric molecular envelope technology for advancing the field of therapeutics.
本综述探讨了通过创新应用聚合物分子包封技术（MET）来提高治疗效果。它深入研究了为实现卓越治疗结果而采用的各种方法，揭示了改善药物递送和生物利用度的策略。MET是一种有前景的方法，可提高难溶性药物的溶解度和生物利用度。该技术涉及使用称为环糊精的环状寡糖分子包封物，它是两亲性分子的超分子组装体，可包裹并溶解疏水性药物分子。这可以通过增加药物表面积和降低其结晶度来进一步提高药物的溶解度。此外，MET还能保护药物不被降解，并增强其跨生物膜的通透性。此外，该综述全面审视了MET，包括其制备方法、在药物包封中的应用以及对其优化治疗结果潜力的评估。通过采用当前的研究和关键发现，本综述为聚合物分子包封技术在推进治疗领域的变革潜力提供了有价值的见解。
