Faccioli Eleonora, Grosso Federica, Dell'Amore Andrea, Delfanti Sara, Zambello Giovanni, Cerbone Luigi, Canu Gianluca, De Angelis Antonina, Sambataro Viola, Pezzuto Federica, Barbieri Paola, Pasello Giulia, Calabrese Fiorella, Rea Federico
Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University Hospital of Padova, Padova, Italy.
Mesothelioma and Rare Cancers Unit, AOU SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Front Oncol. 2024 Apr 15;14:1378530. doi: 10.3389/fonc.2024.1378530. eCollection 2024.
The role of immunotherapy in the multimodal treatment for pleural mesothelioma (PM) is still under investigation, particularly in the preoperative setting. Pathological complete response (pCR) has been previously described after chemotherapy and immunotherapy; however, there is no prior experience reported with immunotherapy alone before surgery. We report the case of a 58-year-old male with biphasic PM treated with immunotherapy, resulting in a major clinical partial response. Following a multidisciplinary evaluation between thoracic surgeons, medical oncologists, pathologists, radiologists and radiation oncologists, the patient underwent surgery with radical intent through a right extended pleurectomy/decortication (eP/D). Histopathological examination of the specimen confirmed a pathological Complete Response (pCR). This case supports the feasibility and potential efficacy of combining preoperative immunotherapy with surgery in the management of advanced PM.
免疫疗法在胸膜间皮瘤（PM）多模式治疗中的作用仍在研究中，尤其是在术前治疗方面。化疗和免疫疗法之后曾有过病理完全缓解（pCR）的报道；然而，此前尚无术前单独使用免疫疗法的经验报告。我们报告了一例58岁双相型PM男性患者接受免疫疗法治疗，结果出现主要临床部分缓解的病例。经过胸外科医生、医学肿瘤学家、病理学家、放射科医生和放射肿瘤学家的多学科评估后，该患者接受了根治性手术，即右扩大胸膜切除术/剥脱术（eP/D）。标本的组织病理学检查证实为病理完全缓解（pCR）。该病例支持术前免疫疗法联合手术治疗晚期PM的可行性和潜在疗效。
