Gutjahr P
Helv Paediatr Acta. 1985;40(6):449-59.
Nineteen second malignant neoplasms (SMN)2 occurring after successful treatment of childhood acute lymphoblastic leukaemia (ALL) are reported from the Federal Republic of Germany. Eighteen children were diagnosed as having ALL within a ten-year period, in which the total number of newly diagnosed ALL was about 5600 in this country. The incidence of a SMN following childhood ALL is calculated to be 2% after a 4-14 years' follow-up period. Of the 19 SMN, 7 are Hodgkin's disease, 1 malignant histiocytosis, 3 thyroid carcinomas, 3 brain tumours, and 5 other solid neoplasms. Second leukaemias were not observed. Immunoregulatory dysfunction, genetic influences and irradiation are the factors which have etiologically been discussed. Chemotherapy seems not to play a major role in the development of SMN after ALL.
据德意志联邦共和国报告，19例儿童急性淋巴细胞白血病（ALL）成功治疗后发生的第二原发性恶性肿瘤（SMN）2。18名儿童在10年内被诊断为ALL，该国新诊断的ALL总数约为5600例。经4至14年的随访期后，儿童ALL后SMN的发病率计算为2%。在这19例SMN中，7例为霍奇金病，1例为恶性组织细胞增多症，3例为甲状腺癌，3例为脑肿瘤，5例为其他实体肿瘤。未观察到第二白血病。免疫调节功能障碍、遗传影响和辐射是病因学上已讨论的因素。化疗似乎在ALL后SMN的发生中不起主要作用。
