单倍体造血干细胞移植的历史：从实验室到临床的历程。
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside.
机构信息
Research assistant, Johns Hopkins University.
Professor of Oncology, Johns Hopkins University School of Medicine, Clinical Director, BMT Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.
出版信息
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.
Abstract
Allogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of the development of haploidentical transplantation at Johns Hopkins University, from the bench to the bedside.
摘要
异基因骨髓移植是治疗肿瘤和非恶性疾病的一种有治愈可能的干预措施。然而，并非所有患者都有 HLA 匹配的供体。因此，开发一种扩大供体库的方法至关重要。移植后环磷酰胺作为移植物抗宿主病预防药物的发展允许安全使用单倍体相合供体，解决了绝大多数有需要的患者的供体可用性问题。本文回顾了约翰霍普金斯大学单倍体移植从基础研究到临床应用的发展历史。
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