探讨噬菌体质粒在基因转移中的作用。

Exploring the role of phage plasmids in gene transfers.

机构信息

Institute of Biochemistry and Biophysics of the Polish Academy of Sciences, Warsaw, Poland.

出版信息

Trends Genet. 2024 Jul;40(7):555-557. doi: 10.1016/j.tig.2024.04.011. Epub 2024 Apr 29.

DOI:10.1016/j.tig.2024.04.011

Abstract

Bacteriophages and plasmids drive horizontal gene transfer (HGT) in bacteria. Phage-plasmids (P-Ps) are hybrids of plasmid and phages. Pfeifer and Rocha recently demonstrated that P-Ps can serve as intermediates in gene exchanges between these two types of elements, identified categories of preferentially transferred genes, and reconstructed gene flows involving phage P1-like P-Ps.

摘要

噬菌体和质粒推动了细菌中的水平基因转移 (HGT)。噬菌体-质粒 (P-Ps) 是质粒和噬菌体的杂交体。Pfeifer 和 Rocha 最近证明，P-Ps 可以作为这两种类型元件之间基因交换的中间体，确定了优先转移基因的类别，并重建了涉及噬菌体 P1 样 P-Ps 的基因流。