Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA.
Exp Mol Med. 2024 May;56(5):1055-1065. doi: 10.1038/s12276-024-01219-w. Epub 2024 May 1.
Neutrophils perform essential functions in antimicrobial defense and tissue maintenance at mucosal barriers. However, a dysregulated neutrophil response and, in particular, the excessive release of neutrophil extracellular traps (NETs) are implicated in the pathology of various diseases. In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis.
中性粒细胞在黏膜屏障的抗微生物防御和组织维持中发挥重要功能。然而，中性粒细胞反应失调，特别是中性粒细胞胞外诱捕网（NETs）的过度释放，与各种疾病的病理学有关。在这篇综述中，我们提供了与中性粒细胞功能相关的基本概念的概述，包括 NET 的形成，并讨论了与流行的口腔疾病牙周炎相关的 NET 激活和功能的机制。
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