Fischer Edgar G, Jones Devin E, Wu Emily S, Rutledge Teresa L
Division of Surgical Pathology and Cytopathology, Department of Pathology, University of New Mexico, Albuquerque, NM, USA.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Int J Surg Pathol. 2025 Feb;33(1):189-194. doi: 10.1177/10668969241248581. Epub 2024 Apr 30.
Malakoplakia is a rare disease that manifests as a histiocytic inflammatory process and most often occurs in the urinary bladder. It is caused by an impaired capacity of histiocytes to kill and digest bacteria. The typical histopathologic findings are sheets of histiocytes with granular eosinophilic cytoplasm and characteristic Michaelis-Gutmann bodies, spherical bodies with a targetoid appearance. Malakoplakia is even rarer in the gynecologic tract, and our literature search found only 21 published patients of malakoplakia involving the endometrium. Here we report a 60-year-old female patient who presented with recurrent pelvic infections and postmenopausal bleeding, which raised concern for an endometrial malignancy. Hysterectomy with salpingo-oophorectomy revealed malakoplakia involving the endometrium and also the right ovary. Michaelis-Gutmann bodies were visible on the intraoperative frozen section that was performed to rule out an endometrial malignancy. We summarize the clinicopathologic findings of the published patients of endometrial malakoplakia.
软斑病是一种罕见疾病，表现为组织细胞性炎症过程，最常发生于膀胱。它是由组织细胞杀灭和消化细菌的能力受损所致。典型的组织病理学表现是成片的组织细胞，其细胞质呈颗粒状嗜酸性，并有特征性的米氏小体，即具有靶样外观的球形小体。软斑病在生殖道更为罕见，我们的文献检索仅发现21例涉及子宫内膜的软斑病患者的报道。在此，我们报告一名60岁女性患者，她因反复盆腔感染和绝经后出血就诊，这引起了对子宫内膜恶性肿瘤的担忧。子宫切除加双侧输卵管卵巢切除术显示软斑病累及子宫内膜及右侧卵巢。术中冰冻切片可见米氏小体，该切片用于排除子宫内膜恶性肿瘤。我们总结了已发表的子宫内膜软斑病患者的临床病理特征。
