Singh Lokjan, Kumar Anil, Rai Maya, Basnet Bibek, Rai Nishant, Khanal Pukar, Lai Kok-Song, Cheng Wan-Hee, Asaad Ahmed Morad, Ansari Shamshul
Department of Microbiology, Karnali Academy of Health Science, Teaching Hospital, Jumla 21200, Karnali, Nepal.
Health Sciences, Asian College of Advance Studies, Purbanchal University, Satdobato 24122, Lalitpur, Nepal.
World J Hepatol. 2024 Apr 27;16(4):517-536. doi: 10.4254/wjh.v16.i4.517.
The coronavirus disease 2019 (COVID-19) pandemic has caused changes in the global health system, causing significant setbacks in healthcare systems worldwide. This pandemic has also shown resilience, flexibility, and creativity in reacting to the tragedy. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection targets most of the respiratory tract, resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some individuals. Although the lung is the primary organ targeted by COVID-19 viruses, the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory failure. However, due to an unorganized immune response and several affected mechanisms, the liver may also experience liver cell injury, ischemic liver dysfunction, and drug-induced liver injury, which can result in respiratory failure because of the immune system's disordered response and other compromised processes that can end in multisystem organ failure. Patients with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the SARS-CoV-2 infection. We thus intend to examine the pathogenesis, current therapy, and consequences of liver damage concerning COVID-19.
2019年冠状病毒病(COVID-19)大流行给全球卫生系统带来了变化,致使全球医疗体系遭受重大挫折。这场大流行在应对这场悲剧时也展现出了韧性、灵活性和创造力。严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染侵袭呼吸道的大部分部位,引发一种名为急性呼吸窘迫综合征的严重疾病,在某些个体中可能致命。尽管肺是COVID-19病毒的主要靶器官,但该疾病的临床症状多种多样,从无症状到呼吸衰竭不等。然而,由于免疫反应紊乱以及多种受影响的机制,肝脏也可能出现肝细胞损伤、缺血性肝功能障碍和药物性肝损伤,这可能因免疫系统的紊乱反应以及其他可能导致多系统器官衰竭的受损过程而引发呼吸衰竭。肝硬化患者或免疫系统受损者可能比其他群体更易因SARS-CoV-2感染而出现更糟糕的结果。因此,我们打算研究与COVID-19相关的肝损伤的发病机制、当前治疗方法及后果。