Ziani Hamid, Nasri Siham, Kamaoui Imane, Skiker Imane
Department of Radiology, Mohammed VI University Hospital, Faculty of Medicine, University Mohammed First, Oujda, Morocco.
Radiol Case Rep. 2024 Apr 24;19(7):2801-2803. doi: 10.1016/j.radcr.2024.03.064. eCollection 2024 Jul.
Toxic leukoencephalopathy (TL) refers to damage to the brain white matter following exposure to toxic agents. Multiple agents are incriminated in this condition, including chemotherapy drugs. 5-Fluorouracil, widely used in oncology, is responsible for neurotoxicity in less than 5% of cases. We report the case of a 54-year-old male patient who presented with neurological symptoms following 5-FU-based chemotherapy for gastric adenocarcinoma, and whose MRI scan revealed signs suggestive of toxic leukoencephalopathy. We also report on the evolution of the abnormalities described on his MRI after 1 year.
中毒性白质脑病（TL）是指接触有毒物质后大脑白质受损。多种物质被认为与这种情况有关，包括化疗药物。广泛应用于肿瘤学的5-氟尿嘧啶在不到5%的病例中会导致神经毒性。我们报告了一例54岁男性患者，他在接受基于5-氟尿嘧啶的胃癌化疗后出现神经症状，其MRI扫描显示有中毒性白质脑病的迹象。我们还报告了1年后其MRI上所描述异常情况的演变。
