Tropeano Giuseppe, Chiarello Maria Michela, Fico Valeria, Brisinda Giuseppe
Emergency Surgery and Trauma Center, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
Department of Surgery, Azienda Sanitaria Provinciale di Cosenza, Cosenza 87100, Italy.
World J Gastrointest Surg. 2024 Apr 27;16(4):974-981. doi: 10.4240/wjgs.v16.i4.974.
In this editorial we comment on the article by Zhang published in a recent issue of the W. Gastrectomy with appropriate lymph node dissection is still standard curative treatment in locally advanced gastric cancer. Several studies point out that gastric cancer surgery is a complex procedure that leads to a high risk of morbidity and mortality. Many factors can contribute to the onset of complications with consequent effects on prognosis and increased mortality. The complications can be divided in complications related to anastomosis, to motility and to surgical site infection. The study presented by Zhang B represent an interesting analysis on the possibility to prevent postoperative morbidity. The study was performed on 131 patients with distal gastric cancer who underwent gastrectomy with D2 lymph node dissection. Of these patients, 16% developed early postoperative complications. The univariate analysis showed that prealbumin level, hypertension, diabetes, history of abdominal surgery, R0 resection, and blood transfusion were factors influencing early postoperative complications after distal gastrectomy. Moreover, the inclusion of the above significant variables in the logistic regression analysis revealed that hypertension, diabetes, a history of abdominal surgery, and blood transfusion were independent predictors of postoperative complications. In conclusion, preoperative and intraoperative factors can be used to establish an early postoperative nomogram model. The results of the study presented by Zhang suggest that the prediction model can be used to guide the detection of postoperative complications and has clinical reference value.
在这篇社论中,我们对张发表在最近一期《W》上的文章进行评论。对于局部晚期胃癌,行适当淋巴结清扫的胃切除术仍是标准的根治性治疗方法。多项研究指出,胃癌手术是一个复杂的过程,会导致较高的发病和死亡风险。许多因素可导致并发症的发生,进而影响预后并增加死亡率。并发症可分为与吻合口、动力和手术部位感染相关的并发症。张B等人提出的研究对预防术后发病的可能性进行了有趣的分析。该研究对131例行D2淋巴结清扫的远端胃癌患者进行。在这些患者中,16%发生了早期术后并发症。单因素分析显示,前白蛋白水平、高血压、糖尿病、腹部手术史、R0切除和输血是影响远端胃切除术后早期并发症的因素。此外,将上述显著变量纳入逻辑回归分析显示,高血压、糖尿病、腹部手术史和输血是术后并发症的独立预测因素。总之,术前和术中因素可用于建立早期术后列线图模型。张等人提出的研究结果表明,该预测模型可用于指导术后并发症的检测,具有临床参考价值。