α-血影蛋白在翅膀中微管驱动的突起解体过程中调节细胞形状变化。
α-Spectrin regulates cell shape changes during disassembly of microtubule-driven protrusions in wings.
作者信息
Tran Ngan Vi, Montanari Martti P, Lubenets Dmitri, Fischbach Léa Louise, Antson Hanna, Okada Yasushi, Ishimoto Yukitaka, Tõnissoo Tambet, Shimmi Osamu
机构信息
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Institute of Biotechnology, University of Helsinki, Helsinki, Uusimaa, Finland.
出版信息
MicroPubl Biol. 2024 Apr 15;2024. doi: 10.17912/micropub.biology.001169. eCollection 2024.
The dynamics of microtubule-mediated protrusions, termed Interplanar Amida Network (IPAN) in pupal wing, involve cell shape changes. The molecular mechanisms underlying these processes are yet to be fully understood. This study delineates the stages of cell shape alterations during the disassembly of microtubule protrusions and underscores the pivotal role of α-Spectrin in driving these changes by regulating both the microtubule and actomyosin networks. Our findings also demonstrate that α-Spectrin is required for the apical relaxation of wing epithelia during protrusion disassembly, indicating its substantial contribution to the robustness of 3D tissue morphogenesis.
微管介导的突起（在蛹翅中称为平面酰胺网络，即IPAN）的动力学涉及细胞形状的变化。这些过程背后的分子机制尚未完全了解。这项研究描绘了微管突起解体过程中细胞形状改变的阶段，并强调了α-血影蛋白通过调节微管和肌动球蛋白网络在驱动这些变化中所起的关键作用。我们的研究结果还表明，α-血影蛋白是突起解体过程中翅上皮顶端松弛所必需的，这表明它对三维组织形态发生的稳健性有重大贡献。
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