Psilopatis Iason, Theocharis Stamatios, Beckmann Matthias W
Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Front Med (Lausanne). 2024 Apr 16;11:1329406. doi: 10.3389/fmed.2024.1329406. eCollection 2024.
Endometriosis constitutes the most common cause of chronic pelvic pain in female patients and is associated with infertility. Although there is no known cause for the disease, it is a heritable condition that is determined by numerous genetic, epigenetic, and environmental aspects. Peroxisome proliferator-activated receptors (PPARs) represent nuclear receptor proteins that control gene expression. By using the MEDLINE and LIVIVO databases we conducted a literature review in order to look into the role of PPARs in the endometriosis pathophysiology and succeeded in revealing 36 pertinent publications between 2001 and 2022. In regards to PPAR expression in endometriosis, PPARγ seems to represent the most studied PPAR isoform in endometriosis and to influence various pathways involved in the disease onset and progression. It's interesting to note that diverse treatment agents targeting the PPAR system have been identified as innovative, effective therapeutic alternatives in the context of endometriosis treatment. In conclusion, PPARs appear to contribute an important role in both endometriosis pathophysiology and therapy.
子宫内膜异位症是女性患者慢性盆腔疼痛的最常见原因，且与不孕有关。尽管该疾病的病因尚不清楚，但它是一种遗传性疾病，由众多遗传、表观遗传和环境因素决定。过氧化物酶体增殖物激活受体（PPARs）是控制基因表达的核受体蛋白。通过使用MEDLINE和LIVIVO数据库，我们进行了一项文献综述，以探究PPARs在子宫内膜异位症病理生理学中的作用，并成功找到了2001年至2022年间的36篇相关出版物。关于PPARs在子宫内膜异位症中的表达，PPARγ似乎是子宫内膜异位症中研究最多的PPAR亚型，并影响该疾病发生和发展所涉及的各种途径。值得注意的是，在子宫内膜异位症治疗方面，已确定多种针对PPAR系统的治疗药物是创新、有效的治疗选择。总之，PPARs似乎在子宫内膜异位症的病理生理学和治疗中都发挥着重要作用。
