Karmakar Abhijit, Silswal Akshay, Koner Apurba Lal
Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal-462066, Madhya Pradesh, India.
J Mater Chem B. 2024 May 22;12(20):4785-4808. doi: 10.1039/d3tb03004k.
This review focuses on the versatile applications of near-infrared (NIR)-responsive smart carriers in biomedical applications, particularly drug delivery and photothermal chemotherapy. These carriers demonstrate multi-responsive theranostics capabilities, including pH-dependent drug release, targeted delivery of chemotherapeutics, heat-mediated drug release, and photothermal tumor damage. Biological samples are transparent to NIR light with a suitable wavelength, and therefore, NIR light is advantageous for deep-tissue penetration. It also generates sufficient heat in tissue samples, which is beneficial for on-demand NIR-responsive drug delivery systems. The development of biocompatible materials with sufficient NIR light absorption properties and drug-carrying functionality has shown tremendous growth in the last five years. Thus, this review offers insights into the current research development of NIR-responsive materials with therapeutic potential and prospects aimed at overcoming challenges to improve the therapeutic efficacy and safety in the dynamic field of NIR-responsive drug delivery.
本综述聚焦于近红外（NIR）响应型智能载体在生物医学应用中的多种用途，尤其是药物递送和光热化疗。这些载体展现出多响应的诊疗能力，包括pH依赖性药物释放、化疗药物的靶向递送、热介导药物释放以及光热肿瘤损伤。生物样品对具有合适波长的近红外光具有透明性，因此，近红外光有利于深层组织穿透。它还能在组织样品中产生足够的热量，这对按需近红外响应型药物递送系统有益。在过去五年中，具有足够近红外光吸收特性和载药功能的生物相容性材料的研发取得了巨大进展。因此，本综述深入探讨了具有治疗潜力的近红外响应型材料的当前研究进展以及前景，旨在克服相关挑战，以提高近红外响应型药物递送这一动态领域中的治疗效果和安全性。
