Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Expert Rev Clin Immunol. 2024 Aug;20(8):945-958. doi: 10.1080/1744666X.2024.2348605. Epub 2024 May 7.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dismal five-year survival rate of less than 10%. Neutrophils are key components of the innate immune system, playing a pivotal role in the PDAC immune microenvironment.
This review provides a comprehensive survey of the pivotal involvement of neutrophils in the tumorigenesis and progression of PDAC. Furthermore, it synthesizes preclinical and clinical explorations aimed at targeting neutrophils within the milieu of PDAC, subsequently proposing a conceptual framework to propel further inquiry focused on enhancing the therapeutic efficacy of PDAC through neutrophil-targeted strategies. PubMed and Web of Science databases were utilized for researching neutrophils in pancreatic cancer publications prior to 2024.
Neutrophils play roles in promoting tumor growth and metastasis in PDAC and are associated with poor prognosis. However, the heterogeneity and plasticity of neutrophils and their complex relationships with other immune cells and extracellular matrix also provide new insights for immunotherapy targeting neutrophils to achieve a better prognosis for PDAC.
胰腺导管腺癌（PDAC）是一种高度侵袭性的恶性肿瘤，其五年生存率不到 10%。中性粒细胞是先天免疫系统的关键组成部分，在 PDAC 的免疫微环境中发挥着关键作用。
本综述全面探讨了中性粒细胞在 PDAC 的肿瘤发生和进展中的关键作用。此外，它综合了针对 PDAC 环境中中性粒细胞的临床前和临床探索，随后提出了一个概念框架，以推动通过针对中性粒细胞的策略增强 PDAC 治疗效果的进一步研究。在 2024 年之前，使用 PubMed 和 Web of Science 数据库研究了与胰腺癌相关的中性粒细胞出版物。
中性粒细胞在 PDAC 中促进肿瘤生长和转移，并与预后不良相关。然而，中性粒细胞的异质性和可塑性及其与其他免疫细胞和细胞外基质的复杂关系也为针对中性粒细胞的免疫治疗提供了新的见解，以实现 PDAC 的更好预后。
