Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
Istituto Clinico Interuniversitario - Consorzio Universitario Humanitas, Rome, Italy.
Early Interv Psychiatry. 2024 Jul;18(7):578-582. doi: 10.1111/eip.13539. Epub 2024 May 1.
This study investigates the psychopathological characteristics of a sample of individuals at ultra-high risk for psychosis with and without comorbid attention-deficit hyperactivity disorder (ADHD).
Twenty-eight subjects (aged 13-21 years; 13 females) with attenuated psychosis syndrome (APS) were recruited in a cross-sectional study and divided into two groups, each with 14 patients, according to the presence or absence of ADHD.
The APS group showed a significantly higher prevalence of negative symptoms than the APS + ADHD group. Other characteristics investigated (positive symptoms, aberrant salience, psychotic-like experiences and prodromal symptoms) did not differ between groups.
The different profiles of negative symptoms in the APS with or without ADHD might suggest the presence of a specific subtype among individuals at ultra-high risk for psychosis. Longitudinal studies with larger samples will provide information about the role of negative symptoms in determining conversion to full psychosis in those people with 'pure' APS and those with APS + ADHD.
本研究旨在探讨处于精神病超高风险状态的个体的精神病理学特征，包括伴有和不伴有注意力缺陷多动障碍（ADHD）的个体。
在一项横断面研究中，招募了 28 名（年龄 13-21 岁；女性 13 名）有精神病前驱症状（APS）的受试者，并根据是否存在 ADHD 将其分为两组，每组各有 14 名患者。
APS 组的阴性症状发生率明显高于 APS+ADHD 组。其他调查的特征（阳性症状、异常突显、类精神病体验和前驱症状）在两组之间没有差异。
在伴有或不伴有 ADHD 的 APS 中，阴性症状的不同特征可能提示在精神病超高风险个体中存在特定的亚群。具有更大样本的纵向研究将提供关于阴性症状在确定那些有“单纯”APS 和 APS+ADHD 的个体向完全精神病转化中的作用的信息。
