Zhang Yi, Wang Feng, Huang YongLi
Department of Radiology, The First People's Hospital of Shuangliu District, (West China Airport Hospital of Sichuan University), Chengdu City, Sichuan Province, China.
Department of Radiology, The First People's Hospital of Shuangliu District, (West China Airport Hospital of Sichuan University), Chengdu City, Sichuan Province, China.
Clinics (Sao Paulo). 2024 Apr 30;79:100367. doi: 10.1016/j.clinsp.2024.100367. eCollection 2024.
This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG).
Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (K), vascular plasma volume fraction (v), extracellular volume fraction (v), and reverse transfer constant (k). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1's prognostic significance, and ROC curve analysis to assess its diagnostic value.
PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with K, and v, and negatively correlated with k, and k.
PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters.
本研究调查了高级别胶质瘤（HGG）中PDZK1表达与动态对比增强磁共振成像（DCE-MRI）灌注参数之间的关系。
对80例HGG患者进行术前DCE-MRI扫描，以获得DCE灌注转移系数（K）、血管血浆容积分数（v）、细胞外容积分数（v）和反向转移常数（k）。检测HGG患者中的PDZK1，并通过Pearson法评估其与DCE-MRI灌注参数的相关性。进行Cox回归分析以确定影响生存的危险因素，同时采用Kaplan-Meier法和对数秩检验评估PDZK1的预后意义，并通过ROC曲线分析评估其诊断价值。
HGG患者中PDZK1上调，提示总体生存和无进展生存较差。此外，PDZK1表达可区分III级和IV级HGG。PDZK1表达与K和v呈正相关，与k和k呈负相关。
HGG中PDZK1上调，提示生存较差，并可区分HGG患者的肿瘤分级。PDZK1表达与DCE-MRI灌注参数相关。
