Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Phytochemistry. 2024 Oct;226:114118. doi: 10.1016/j.phytochem.2024.114118. Epub 2024 Apr 29.
Chemical investigation on the leaves of Michelia champaca L. (Magnoliaceae) led to the isolation of five previously undescribed phenylethanoid glycosides (PhGs), 4-O-β-d-glucopyranosyl-acteoside (1), 4‴-O-(6-O-E-caffeoyl)-β-d-glucopyranosyl-acteoside (2), 4‴-O-(6-O-E-caffeoyl)-β-d-glucopyranosyl-isoacteoside (3), 6""-O-E-feruloyl-echinacoside (4), and 6""-O-p-E-coumaroyl-echinacoside (5), together with eighteen known PhGs. Their structures were determined by spectroscopic and chemical methods. All the known PhGs except acteoside (8) were not previously reported in the genus. Twenty-one PhGs exhibited more potent DPPH radical scavenging activity and FRAP than l-ascorbic acid (l-AA), and twenty-two PhGs showed better ABTS radical cation scavenging activity than l-AA. In addition, twelve PhGs displayed more potent cellular reactive oxygen species scavenging activity than curcumin. The results revealed that the leaves of M. champaca are a rich source of phenylethanoid glycosides and antioxidants.
对Michelia champaca L.（木兰科）叶片的化学研究导致分离出五种以前未描述的苯乙醇苷（PhGs），分别为 4-O-β-d-吡喃葡萄糖基-acteoside（1）、4‴-O-（6-O-E-咖啡酰基）-β-d-吡喃葡萄糖基-acteoside（2）、4‴-O-（6-O-E-咖啡酰基）-β-d-吡喃葡萄糖基-isoacteoside（3）、6""-O-E-阿魏酸酰基-echinacoside（4）和 6""-O-p-E-香豆酰基-echinacoside（5），以及十八种已知的 PhGs。通过光谱和化学方法确定了它们的结构。除 acteoside（8）外，所有已知的 PhGs以前都未在该属中报道过。21 种 PhGs 对 DPPH 自由基的清除活性和 FRAP 均强于 l-抗坏血酸（l-AA），22 种 PhGs 对 ABTS 自由基阳离子的清除活性强于 l-AA。此外，12 种 PhGs 对细胞活性氧的清除活性强于姜黄素。结果表明，Michelia champaca 的叶子是苯乙醇苷和抗氧化剂的丰富来源。
